608-30-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 608-30-0, name is 2,6-Dibromoaniline, A new synthetic method of this compound is introduced below.
4-tert-Butylphenylboronic acid (4.81 g, 27.0 mmol) dissolved in ethanol (18 mL) and 2 M Na2CO3 (36 mL, 72 mmol) were added to a solution of 2,6-dibromoaniline (2.258 g, 9.0 mmol) in toluene (90 mL). To this solution, Pd(PPh3)4 (1.26 g, 1.0 mmol) was added. The mixture was heated to reflux for 72 h. After cooling to room temperature, the mixture was filtered and an excess of aqueous HCl was slowly added to the filtrate until no more white solid precipitated. The residue was suspended in diethyl ether after filtration and then an excess of 2 M Na2CO3 was slowly added until the solid was totally dissolved. The organic layer was dried over Na2SO4 and then the solvent was evaporated to give white solid (1.80 g, yield 56%). 1H NMR (500 MHz, CDCl3, delta in ppm): 7.47-7.52 (m, 8H, Ar-Hm), 7.15 (d, 2H, Ar-Ho), 6.89 (t, 1H, Ar-Hp), 3.95 (s,2H, NH2), 1.40 (s, 18H, CH3).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Pan, Huijie; Zhu, Liang; Li, Jiewei; Zang, Dandan; Fu, Zhisheng; Fan, Zhiqiang; Journal of Molecular Catalysis A: Chemical; vol. 390; (2014); p. 76 – 82;,
Bromide – Wikipedia,
bromide – Wiktionary