58971-11-2, Name is 3-Bromophenethylamine, 58971-11-2, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
A mixture of 4-iodobenzoic acid (10.0 g, 40.32 mmol) in thionyl chloride (40 mL, 40.32 mmol) was stirred at 80 C for 16 hours. The reaction mixture was concentrated to give4-iodobenzoyl chloride (10.7 g, 99%) as a white solid. To a solution of 2-(3-bromophenyl)ethylamine (6.0 g, 29.99 mmol) and triethylamine (20 mL, 149.94 mmol) in dichioromethane (100 mL) at 0 C was added 4-iodobenzoyl chloride prepared above (9.6 g, 35.99 mmol) portionwise. The resulting mixture was stirred at 25 C for 4 hours and was then diluted with DCM (500 mL). Water (100 mL) was added to the reaction mixture and twolayers were separated. The organic layer was dried over anhydrous sodium sulfate, and was concentrated to give the title compound as a white solid (12 g, 93%). ?H NMR (400 MHz, CDC13) oe 7.75 (d, J= 8.4 Hz, 2H), 7.42 – 7.36 (m, 3H), 7.22 – 7.09 (m, 2H), 6.15 (s, 1H), 3.69- 3.64 (m, 2H), 2.91 – 2.87 (m, 2H).
Statistics shows that 3-Bromophenethylamine is playing an increasingly important role. we look forward to future research findings about 58971-11-2.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; LABADIE, Sharada; LIANG, Jun; ORTWINE, Daniel Fred; WANG, Xiaojing; ZHANG, Birong; ZBIEG, Jason; VINOGRADOVA, Maia; WANG, Tao; (150 pag.)WO2017/174757; (2017); A1;,
Bromide – Wikipedia,
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