As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 583-70-0 name is 2,4-Dimethylbromobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 583-70-0
1-bromo-2,4-dimethylbenzene 12a (1.0 g, 5.40 mmol), bis(pinacolato)diboron (1.90 g, 8.10 mmol),1,1 ‘-bis (diphenylphosphino) ferrocene] dichloropalladium (198 mg, 0.27 mmol) and potassium acetate (1.30 g, 13.5 mmol) was dissolved in 50 mL of ethylene glycol dimethyl ether and heated to reflux for 3 hours. Filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography using eluent system B to give the title product, 2-(2,4-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 12b (700 mg, yellow oil), yield: 56.0%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,4-Dimethylbromobenzene, and friends who are interested can also refer to it.
Reference:
Patent; SHANGHAI HENGRUI PHARM CO LTD; JIANGSU HENGRUI MEDICINE CO LTD; Lyu, HEJUN; DONG, QING; FEI, HONGBO; JIANG, HONGJIAN; SONG, PENG; (114 pag.)CN103030646; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary