393-36-2, Name is 4-Bromo-3-(trifluoromethyl)aniline, 393-36-2, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
Starting material laa;4-Bromo-N -ethyl-5-trifluoromethyl-benzene-l,2-diamineStep 1: N-(4-bromo-2-nitro-5-trifluoromethyl-phenyl)-acetamideFollowing the method of Ognyanov, V. L, et. al; /. Med. Chem.; 49(12); 3719(2006), under a nitrogen purge, 4-bromo-3-trifluoromethylaniline (7.2 g; 0.03 mol) was added to acetic anhydride (30 mL) in a 100 mL round-bottomed flask. After stirring for 16 h at room temperature, solvent was removed under reduced pressure to obtain a white solid, which was used as-is for the nitration step.
Statistics shows that 4-Bromo-3-(trifluoromethyl)aniline is playing an increasingly important role. we look forward to future research findings about 393-36-2.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/56150; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary