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40161-54-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 40161-54-4, name is 1-Bromo-2-fluoro-4-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows.
Example 14; ralphac-(35r,4i?)-7V-cyclopropyl-4- [2-fluoro-4-(trifluoromethyl)phenyl] -4-hydroxy-iV- [3 -(2- methoxyethoxy)-5 -(3 -methoxypropyl)benzyl]piperidine-3 -carboxamide; Step 1: rac-tert-butv (3?4i?V3-alphacvclopropyir3-q-methoxyethoxy)-5-(3- methoxypropyDbenzyll amino } carbonyl)-4- [2-fluoro-4-(trifluoromethyl)phenyl] -4- hydroxypiperidine- 1 -carboxylate; ?-BuLi (2.50 M in THF, 3.11 eq.) was added to a stirred solution of l-bromo-2- fluoro-4-(trifluoromethyl)benzene (3.24 eq.) in THF (1.6 M) at -78 C. The mixture was stirred at -78 0C for 15 min then MgBr2-Et2O (0.4 M in THF, 3.32 eq.) was added dropwise. The mixture was stirred -78 C for 30 min. The resulting solution was cannulated into a solution of keto amide 3.1 (1 eq.) in THF (0.15 M) at -78 C. The reaction mixture was stirred at -78 C for 1 hr then allow to warm slowly to rt with stirring over 12 h. The mixture was quenched with saturated NH4Cl, diluted with Et2O. The organic extract was washed with brine, dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by column chromatography on silica gel (10-75% EtOAc in hexanes) to give the title compound as an oil.
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Reference:
Patent; MERCK FROSST CANADA LTD.; WO2009/70869; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary