Adding a certain compound to certain chemical reactions, such as: 68322-84-9, name is 2-Bromo-1-fluoro-4-(trifluoromethyl)benzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 68322-84-9, 68322-84-9
General procedure: Example 14 l,5-anhydro-2,3-dideoxy-3-{[(2R,3aR,6aR)-3a-({(lS,4S)-5-[2-fluoro-5- (trifluoromethyl)phenyl]-2,5-diazabicyclo[2.2.1 ]hept-2-yl} carbonyl)octahydropentalen-2- yl] amino } -4-O-methyl-D-erythro-pentitol To a solution of Example 1 IB (70 mg, 0.193 mmol), 2-bromo-l-fluoro-4- (trifluoromethyl)benzene (117 mg, 0.483 mmol) in toluene (1 mL) was added 2- dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl (9 mg, 0.02 mmol), Pd2(dba)3 (18 mg, 0.02 mmol) and sodium t-butoxide (26 mg, 0.27 mmol) was then stirred at 120 C for 12 hours. The reaction was cooled and water was added. The reaction mixture was extracted with ethyl acetate. The organic fractions were concentrated and the residue was purified by preparative HPLC (Column: Phenomenex Synergi CI 8 150*30etaiotaetaiota*4muiotaeta; Mobile phase: from 25% acetonitrile in water (0.225% TFA) to 45% acetonitrile in water (0.1 % TFA)) to give the title compound as a trifluoroacetic acid salt. 1H NMR (400 MHz, CD3OD) delta (ppm): 7.20 (m, 1H), 7.01 (m, 2H), 4.55-4.85 (m, 3H), 4.29 (m, 1H), 3.47-4.04 (m, 12H), 1.60-2.50 (m, 13H), 1.42 (m, 2H); MS (ESI) m/z 526 (M+H)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1-fluoro-4-(trifluoromethyl)benzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ABBOTT LABORATORIES; ABOTT LABORATORIES TRADING (SHANGHAI)COMPANY, LTD.; MEYER, Michael D.; WANG, Xueqing; GUO, Tao; WEI, Robert; WANG, Lijuan Jane; WO2013/149376; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary