A common heterocyclic compound, 1647-26-3, name is 1-Bromo-2-cyclohexylethane, molecular formula is C8H15Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1647-26-3.
Example 12: N-trans-(2-cyclohexylethyl)-2-phenylcyclopropanamine hydrochloride; To a solution Intermediate B (1.5g, 6.42 mmol) in Dimethylformamide (DMF, 30 mL) was added sodium hydride (0.38 mg, 9.64 mmol) and the suspension was stirred 30 min at room temperature. 1 -Cyclohexylethyl bromide (1.2 mL, 7.71 mmol) was then added and the suspension stirred 12h at room temperature. Solvents were evaporated and the residue was dissolved in dichloromethane (60 mL) and washed with water, brine and water, dried and concentrated. The obtained solid was purified by column chromatography to afford the Boc-protected product (1.4 g). This solid was dissolved in dichloromethane and HC1 (15 mL) was added. The precipitate was filtered, washed with cold ether and dried to afford the desired product (1.56 g, 88%). -NMR (CDC13) delta (ppm): 1.05 (m, 13H), 1 .2 1 (m, 1 H), 1 .44 (m, 1 H), 2.41 (m, 1 H), 2.92 (m, 1 H), 3.20 (m, 2H), 7.16-7.25 (m, 5H), 8.2 (bs, 2H). MS (M+H): 245.0.
The synthetic route of 1-Bromo-2-cyclohexylethane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ORYZON GENOMICS S.A.; ORTEGA MUNOZ, Alberto; CASTRO-PALOMINO LARIA, Julio; FYFE, Matthew Colin Thor; WO2011/131697; (2011); A1;,
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