327-51-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, This compound has unique chemical properties. The synthetic route is as follows.
Into a three-necked flask, to 1,4-dibromo-2,5-difluorobenzene (37.5g, 138.0mmol), 2-nitrophenylboronic acid (23.0g, 138.0mmol), 2M Na2CO3 aqueous solution (138mL, 276mmol), DME (275mL), toluene (275mL), Pd[PPh3]4 (8.0g, 6.9mmol) was added, this mixture was refluxed for 8 hr under Ar atmosphere. After the reaction was cooled to room temperature. The sample was transferred to a separatory funnel, added water (250mL), and extracted with CH2Cl2. After drying with MgSO4, filtered, and concentrated. Purification of a sample was purified by silica gel column chromatography to give a white solid. Yield 26.1g, 60% yield.
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Reference:
Patent; Idemitsu Kosan Corporation; Kato, Tomoki; Numata, Masaki; Yoshida, K.; Nishimura, Kazuki; Eiwakuma, Toshihiro; Hosokawa, Chisio; (108 pag.)KR101500796; (2015); B1;,
Bromide – Wikipedia,
bromide – Wiktionary