39478-78-9, name is 5-Bromo-2-methylaniline, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 39478-78-9
General procedure: An equimolar mixture of isatin/5-bromoisatin and an aromatic primary amine were introduced into an Erlenmeyer flask. Ethanol (1 mL) and a few drops of acetic acid were added. The Erlenmeyer flask was placed in an ultrasonic bath filled with water (80 Hz,100%), the temperature was adjusted at 40C. At the end of the reaction (monitored by TLC), the product obtained by filtration was recrystallized from ethanol. For the reactions carried out in microwave Biotage, the reagents in 4 mL of ethanol were put in a magnetic stir bar for 2-5 mL vial and the temperature was set at 150C, 160C then 180C.
Statistics shows that 39478-78-9 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-2-methylaniline.
Reference:
Article; Chemchem, Meryem; Menacer, Rafik; Merabet, Naima; Bouridane, Hamida; Yahiaoui, Samir; Moussaoui, Sadjia; Belkhiri, Lotfi; Journal of Molecular Structure; vol. 1208; (2020);,
Bromide – Wikipedia,
bromide – Wiktionary