40161-54-4, Adding some certain compound to certain chemical reactions, such as: 40161-54-4, name is 1-Bromo-2-fluoro-4-(trifluoromethyl)benzene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 40161-54-4.
Example 42: N-(5-Fluorothiazol-2-yl)-5-(2-(4-methylpiperazin-l-yl)-4- (trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(lH)-sulfonamide Step 1 : 5-(2-(4-Methyl-lH-imidazol-l-yl)-4-(trifluoromethyl)phenyl)isoquinoline A suspension of sodium hydride 60% (0.330 g, 13.75 mmol) in 8 mL DMF was cooled to 0 C and was treated with 4-methyl-lH-imidazole (0.676 g, 8.23 mmol). After stirring for 40 minutes, l-bromo-2-fluoro-4-(trifluoromethyl)benzene (1.180 ml, 8.23 mmol) was added, and the reaction mixture was heated to 120 C for 90 minutes. At this point Cl2Pd(AmPhos) (Sigma-Aldrich, St. Louis, MO, 0.291 g, 0.412 mmol), isoquinolin-5- ylboronic acid (1.424 g, 8.23 mmol), potassium phosphate (6.99 g, 32.9 mmol), 16 mL dioxane and 12 mL water were added, and the reaction mixture was heated to 120 C overnight. The reaction mixture was poured into saturated aHC03 solution and was extracted with DCM. The organics were concentrated then purified by reverse phase column chromatography [RediSep Gold C18 150g, 15 to 100% (0.1% NH40H in MeOH)/(0.1% NH40H in water)] yielding 5-(2-(4-methyl-lH-imidazol-l-yl)-4- (trifluoromethyl)phenyl)isoquinoline (1.435 g, 4.06 mmol) as an about 4: 1 mixture of isomers.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 40161-54-4.
Reference:
Patent; AMGEN INC.; DINEEN, Thomas; KREIMAN, Charles; WEISS, Matthew; GEUNS-MEYER, Stephanie; WO2013/134518; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary