In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 615-59-8 as follows. 615-59-8
3,6-Dibromobenzylbromide In a 250 ml three-necked round-bottom flask equipped with a reflux condenser, thermometer, dropping funnel with pressure-equalizing, and magnetic stirring bar, and containing 74.9 g (0.30 mol) of 3,6-dibromotoluene, 15.5 ml (47.9 g, 0.30 mmol) of bromine was added dropwise under exposure to 500 W lamp for 3 hours at 190¡ã C. The resulting mixture was cooled to room temperature. Fractional distillation gave colorless liquid, b.p. 132-135¡ã C./3 mm Hg. Yield 84.3 g (85percent). Anal. calc. for C7H5Br3: C, 25.57; H, 1.53. Found: ¡ã C, 25.81; H, 1.62. 1H NMR (CDCl3): delta 7.59 (m, 1H, 5-H), 7.43 (m, 1H, 3-H), 7.28 (m, 1H, 3-H), 4.52 (s, 2H, CH2). 13C NMR (CDCl3): delta 138.9, 134.6, 134.0, 133.1, 123.0, 121.5, 32.2.
According to the analysis of related databases, 615-59-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Voskoboynikov, Alexander Z.; Ryabov, Alexey N.; Nikulin, Mikhail V.; Lygin, Alexander V.; Coker, Catalina L.; Canich, Jo Ann M.; US2007/135595; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary