In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10485-09-3, name is 2-Bromoindene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Bromoindene
A 2.02 g (83.1 mmol) piece of magnesium was charged into a sufficiently dried and argon-replaced 200 mL reactor, and stirred vigorously while heating under reduced pressure for 30 minutes.Cool to room temperatureAfter that, a piece of iodine and 25 mL of tetrahydrofuran were charged and stirred. A 20 mL dilute solution of 3.92 g (20.1 mmol) of 2-bromoindene in 20 mL of tetrahydrofuran was slowly added, and the mixture was heated to reflux in an oil bath at 80 C. for 1 hour.This reaction solution was slowly added to a solution of 12.0 mL (100 mmol) of dimethylsilyldichloride in 10 mL of n-hexane under cooling with cooling, and stirring was continued for 18 hours while returning to room temperature.After distilling off the solvent of the reaction solution and unreacted dimethylsilyl dichloride, 20 mL of tetrahydrofuran and 1.90 mL (20.2 mmol) of 1,3-dimethyl-2-imidazolidinone were added to the residue.9.79 g of n-butylcyclopentadiene solution (25 wt% of tetrahydrofuran solution, 20.0 mmol) and 20 mL of tetrahydrofuran are charged into a sufficiently dried, argon-substituted 100 mL reactor, and 12.5 mL of n-butyllithium solution (hexane solution) , 1.60M, 20.0 mmol) was added and stirred at room temperature for 2 hours.This solution was added dropwise to the previously diluted reaction residue diluted solution cooled to -78 C., and stirring was continued for 17 hours while gradually returning to room temperature.Saturated aqueous ammonium chloride solution was added, the soluble matter was extracted with n-hexane, the obtained fraction was washed with saturated brine and dried over anhydrous magnesium sulfate.After magnesium sulfate is filtered, the filtrate is evaporated and the obtained residue is purified by silica gel column chromatography to obtain the target compound represented by the following formula (AL) (hereinafter referred to as compound (AL)) Was obtained as an isomer mixture of 4.65 g (yield 79%).
The synthetic route of 10485-09-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mitsui Chemicals Chemicals company; Tanaka, Kenichi; Harada, yasuyuki; (44 pag.)JP2019/69920; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary