Synthetic Route of 149910-98-5, A common heterocyclic compound, 149910-98-5, name is 7-Bromoisochroman, molecular formula is C9H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a round-bottom flask is added in 5- bromine different chroman (1.0mmol), acetonitrile (2 ml), trimethyl silicon base nitrine (3.0mmol), in 80 C in the heating module 1-2 minutes, then adding CuBr 2 (2.0mmol), then after sealing the system 80 C heating reaction under 3 hours, the reaction using the ethyl acetate extraction, concentration by the simple column chromatography (eluting agent using petroleum ether (60-90 C) and ethyl acetate mixed solvent) to get product 5-bromo-2 – (2-hydroxy ethyl) benzonitrile, the yield is 60%.
The synthetic route of 149910-98-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hangzhou Normal University; Wang, Min; Tao, Lianzhi; Zhang, Min; Yang, Pengfei; (39 pag.)CN105330565; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary