Synthetic Route of 86845-27-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 86845-27-4 as follows.
(44-1) After N-bromosuccinimide (1.49 g, 6.63 mmol) and 2,2′-azobis(isbutyronitrile) (20 mg) were added to a solution of 4-bromo-1-methyl-2-(trifluoromethyl)benzene (2.0 g, 8.4 mmol) in carbon tetrachloride (20 ml), the mixture was heated under reflux for 5 hours. The temperature of the reaction mixture was returned to room temperature and the residue obtained by removing the solvent under reduced pressure was subjected to silica gel column chromatography (eluding solvent: n-hexane) to give crude 4-bromo-1-bromomethyl-2-(trifluoromethyl)benzene.
According to the analysis of related databases, 86845-27-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Daiichi Sankyo Company, Limited; EP1806332; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary