Synthetic Route of 103273-01-4,Some common heterocyclic compound, 103273-01-4, name is 2-Bromo-4-(tert-butyl)aniline, molecular formula is C10H14BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 2: Synthesis of 2-amino-3′,5-di-t-butylbiphenyl 3-t-butylphenylboronic acid (4.0 g, 22.4 mmol), 2-bromo-4-t-butylaniline (4.3 g, 18.7 mmol), palladium(II) acetate (0.11 g, 0.468 mmol), triphenylphosphine (0.5 g, 1.8 mmol) and was added 2 M solution of potassium carbonate in 25 of ethylene glycol dimethyl ether in the 36 . The reaction mixture was heated under reflux for 18 hours. Cool the reaction to room temperature, and separating the aqueous phase from the organic phase. The aqueous phase was extracted with ethyl acetate. The organic extracts were combined, dried over magnesium sulfate, filtered and concentrated. It was purified by column chromatography using 20% ethyl acetate and hexane the crude product as an eluent. Collected as a pure product of 2-amino-3 ‘, 5-di -t- butyl biphenyl (3.0 g, 57% yield) of a white solid, and its NMR is consistent with the proposed structure.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromo-4-(tert-butyl)aniline, its application will become more common.
Reference:
Patent; UNIVERSAL DISPLAY CORPORATION; NOLIS, DAVID B; LIN, CHOOK; MCKINSEY, PETER BODON; CHAI, CHUI LEE; WALTERS, ROBERT W; PIERS, SCOTT A; BROWN, CORY S; IGOR, WALTER H; (101 pag.)KR2016/30582; (2016); A;,
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