Related Products of 53078-85-6, These common heterocyclic compound, 53078-85-6, name is 2-Bromo-5-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Aniline 1: Step 1: A mixture of 2-bromo-5-methylaniline (220 mg, 1 mmol) and vinylboronic acid pinacol ester (185 mg, 1.2 mmol) in Dioxane/Water (4: 1, Volume: 2.5 ml) was treated with potassium carbonate (276 mg, 2 mmol) and Pd(Ph3P)4(12 mg, 0.01 mmol). The mixture was heated at 100 C for 16 h and cooled to rt. The reaction was quenched with water and the aqueous layer was extracted with ethyl acetate. The organic layer was washed with brine, dried over Na2S04, and concentrated. The crude product was purified by chromatography (hexanes to 10:90 EA/Hex) to afford the product in 17% yield (28 mg, 0.17 mmol).
The synthetic route of 53078-85-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE UNITED STATES OF AMERICA; UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; BOXER, Matthew Brian; ROHDE, Jason Matthew; PRAGANI, Rajan; LIU, Li; DAVIS, Mindy Irene Emily; BRIMACOMBE, Kyle Ryan; SHEN, Min; SIMEONOV, Anton; KARAVADHI, Surendra; URBAN, Daniel Jason; JADHAV, Ajit; WANG, Xiaodong; MCIVER, Andrew Louis; (407 pag.)WO2016/106331; (2016); A1;,
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