In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4333-56-6 as follows. Product Details of 4333-56-6
To a stirred solution of cyclopropyl bromide (4.0 mL, 50 mmol) in 120 mL of ether at-78C was added dropwise a 1.7M solution of t-butyllithium in pentane (44.5 mL, 75.7 mmol). After 10 min, cooling bath was removed, stirring was continued for 1.5 h. The mixture was cooled again in a-78C bath, and 3-furaldehyde (3.5 mL, 41.9 mmol) was added. Reaction was continued for 1 h, and quenched with a saturated NH4CI aqueous solution. The aqueous mixture was extracted with CH2CI2 (100 mL x 3). The organic extracts were washed with brine, dried by Na2SO4, filtered, and concentrated in vacuo to give 5.3 g (91 %) of the alcohol product as a yellow oil.
According to the analysis of related databases, 4333-56-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2005/68460; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary