Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21524-34-5, name is 2-Bromo-1,3,5-triisopropylbenzene, A new synthetic method of this compound is introduced below., COA of Formula: C15H23Br
General procedure: Pd(dba)2/1-catalyzed amination of aryl halides: An oven-dried Schlenk tube equipped with a magnetic stirring bar was charged with Pd(dba)2 (5.8 mg, 0.010 mmol), ligand 1 (8.6 mg, 0.020 mmol) and tBuONa (134 mg, 1.4 mmol). The flask was capped with a rubber septum, evacuated, and then flushed with argon. This cycle was repeated three times. Amine (1.2 mmol), aryl halide (1.0 mmol) and DME (4 mL) were then successively added by syringe. The tube was stirred at room temperature for several minutes and then placed into a preheated oil bath (120 C) for the time period as indicated in tables. After completion of reaction as judged by GC analysis, the reaction tube was allowed to cool to room temperature and the reaction mixture was adsorbed onto silica gel, and then purified by column chromatography (hexane/ethyl acetate as eluent) to afford the desired product.
The synthetic route of 21524-34-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Hao, Xiaowei; Yuan, Jia; Yu, Guang-Ao; Qiu, Ming-Qiang; She, Neng-Fang; Sun, Yue; Zhao, Cui; Mao, Shu-Lan; Yin, Jun; Liu, Sheng-Hua; Journal of Organometallic Chemistry; vol. 706-707; (2012); p. 99 – 105;,
Bromide – Wikipedia,
bromide – Wiktionary