1647-26-3, name is 1-Bromo-2-cyclohexylethane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 1647-26-3
Example 58A Di-tert-butyl {2-[6-(2-cyclohexylethoxy)-1-benzofur-3-yl]-2-oxoethyl}[2-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)ethyl]malonate To a mixture of 300 mg (0.53 mmol) of the compound from Example 55A in 3 ml of acetonitrile were added at RT 221 mg (1.60 mmol) of potassium carbonate, followed by 306 mg (1.60 mmol) of 2-(bromoethyl)cyclohexane and the mixture was stirred under reflux for 4 h. After cooling to RT, the mixture was admixed with water and extracted twice with ethyl acetate. The combined organic phases were washed once with saturated sodium chloride solution, dried over magnesium sulphate, filtered and concentrated. The residue was purified by means of column chromatography (40 g of silica gel, mobile phase: cyclohexane/ethyl acetate 85:15). 140 mg (37% of theory, purity 96%) of the title compound were obtained. LC/MS (Method 1, ESIpos): Rt=1.71 min, m/z=674 [M+H]+.
The synthetic route of 1647-26-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BECK, Hartmut; LI, Volkhart Min-Jian; CANCHO GRANDE, Yolanda; TIMMERMAN, Andreas; BROHM, Dirk; JOeRIssEN, Hannah; BOGNER, Pamela; GERISCH, Michael; LANG, Dieter; (120 pag.)US2017/121315; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary