Adding a certain compound to certain chemical reactions, such as: 4333-56-6, name is Bromocyclopropane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4333-56-6, name: Bromocyclopropane
Synthesis of l-bromo-2-cyclopropoxy-4-fluorobenzene [0520] To a stirred solution of 2-bromo-5-fluorophenol (1 g, 5.23 mmol) in DMF (5 mL) under argon atmosphere were added cesium carbonate (5 g, 15.69 mmol), potassium iodide (130 mg, 0.78 mmol) and bromocyclopropane (1.2 mL, 15.70 mmol) at RT. The reaction mixture was stirred at 180-220C for 3 h. After consumption of the starting materials (monitored by TLC), the reaction was diluted with water (50 mL) and extracted with EtOAc (2 x 50 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by column chromatography using 5% EtOAc:hexanes to afford l-bromo-2-cyclopropoxy-4-fluorobenzene (1 g, 83%) as colorless oil. 1H-NMR (OMSO-de, 400 MHz): delta 7.60 (t, 1H), 7.27 (d, 1H), 6.80 (t, 1H), 4.00-3.96 (m, 1H), 0.87-0.82 (m, 2H), 0.72-0.69 (m, 2H); TLC: 10% EtOAc/hexane (R 0.7).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Bromocyclopropane, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66697; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary