Reference of 627871-16-3, These common heterocyclic compound, 627871-16-3, name is 5-Bromo-4-fluoro-2-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 250 mL round-bottomed flask was placed 4-(pyridin-2-ylmethoxy)benzoic acid (3.4 g, 14.7) in DCM (50 mL) to give a suspension. To the solution, SOCl2 (22.29 mL, 305.37 mmol) was added. The mixture was stirred at RT overnight. Concentration removed SOCl2 and DCM to give crude 4-(pyridin-2-ylmethoxy)benzoyl chloride. To the residue was added 5-bromo-4-fluoro-2-methylaniline (3.0 g, 14.70 mmol), DIPEA (6.42 mL, 36.76 mmol), and DCM (60 mL) to give a black solution. The reaction was stirred at RT overnight. Concentration under reduced pressure gave the crude product, which was purified by ISCOMPLC (0-6% MeOH/DCM) to give the title compound.
Statistics shows that 5-Bromo-4-fluoro-2-methylaniline is playing an increasingly important role. we look forward to future research findings about 627871-16-3.
Reference:
Article; Bodnarchuk, Michael S.; Brassil, Patrick; Dakin, Les; Daly, Kevin; Godin, Robert; Hattersley, Maureen M.; Hird, Alexander W.; Janetka, James W.; John Russell, Daniel; Redmond, Sean; Su, Qibin; Yang, Bin; Zheng, Xiaolan; Bioorganic and medicinal chemistry; vol. 28; 2; (2020);,
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