Reference of 50548-45-3, A common heterocyclic compound, 50548-45-3, name is 1-Bromodibenzo[b,d]furan, molecular formula is C12H7BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a 500 ml round bottom flask in a nitrogen atmosphereCompound 1-Bromobenzofuran (10.0 g, 40.65 mmol),1,1′-biphenyl] -4-yl) – [1,1 ‘: 3′, 1 ” – terphenyl(N – ([1,1’-biphenyl] -4-yl) – [1,1 ‘: 3’, 1 ” – terphenyl]”(17.75 g, 44.72 mmol) Xylene(Xylene) in 260 mlAfter completely dissolvedSodium tert-butoxide(sodium tertbutoxide) (5.08 g, 52.85 mol) was added,Bis (tri-tert-butylphosphine) palladium (0)(Bis (tri-tert-butylphosphine) palladium (0)) (0.21 g, 0.41 mmol)And the mixture was heated and stirred for 7 hours.The temperature was lowered to room temperature and filteredAfter the salt was removed, xylene was concentrated under reduced pressure and recrystallized from ethyl acetate (200 ml) to obtain Compound (3) (16.17 g, yield: 71percent).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; LG CHEM, LTD.; KIM, Jin Joo; HONG, Sung gil; CHA, Yong bum; (27 pag.)KR2017/94665; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary