Related Products of 59734-92-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59734-92-8, name is 1-Bromo-2-cyclohexylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
46.7 ml (117 mmol) of 2.5M n-butyl lithium solution in hexane is slowly treated at -73C with24.0 g (97.3 mmol) of 1-bromo-2-cyclohexyl-benzene in 200 ml of THF under argonatmosphere, letting the temperature not rise above -70C. Addition is completed after 90minutes, giving a white suspension, and stirring continued at -73C during 30 minutes. 15.3g (147 mmol) of trimethylborate are slowly added during 20 minutes at -73C, letting the temperature not rise above -70C. The colorless solution is further stirred at -74C during one hour, and the temperature let raising to room temperature during three hours. The colorless solution is further stirred at room temperature during 16 hours, followed by theslow addition of 30 ml of 10% aqueous hydrochloric acid solution during 15 minutes. Stirring is continued at room temperature during three hours, and the reaction mixture two times extracted with 100 ml of ethyl acetate. The organic phase is dried over sodium sulfate, concentrated under vacuum, and further purified by chromatography (silica gel, heptane/ethyl actate 4:1), giving the title product as an off-white solid (yield: 10.1 g (51%)).1HNMR (400 MHz, CDCI3): = 1.24-2.11 (m, 10 H), 3.72-3.91 (m, I H), 7.33 (dt, I H), 7.49 (d, I H), 7.56 (dt, I H), 8.26 (dd, I H).
The synthetic route of 1-Bromo-2-cyclohexylbenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BASF SE; MURER, Peter; BATTAGLIARIN, Glauco; DORMANN, Korinna; METZ, Stefan; WAGENBLAST, Gerhard; BENEDITO, Flavio Luiz; WATANABE, Soichi; LENNARTZ, Christian; GESSNER, Thomas; WO2015/14835; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary