In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7745-91-7 as follows. Product Details of 7745-91-7
(TrifluoromethvDBenzamide (Intermediate 33″)33[0232] To a solution of 3-bromo-4-methylbenzenamine (0.82 g, 4.4 mmol) in anhydrous CH2Cl2 (40 mL) was added 3-(trifluoromethyl)benzoyl chloride (0.72 ml, 4.85 mmol) and triethylamine (2.5 ml, 17.6 mmol). The mixture was stirred overnight at room temperature. The saturated NaHCCb (80 mL) was added and the mixture was stirred for 5 min. The organic layer was separated and aqueous was extracted with CH2CI2 (3 x 20 mL). The combined organic solution was dried (Na2SO4). The solvent was removed in vacuo. The title compound was afforded as a yellow solid (1.48 g, 94%).
According to the analysis of related databases, 7745-91-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TARGEGEN, INC.; WO2008/8234; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary