22034-13-5, name is 4-Bromobenzo[c][1,2,5]thiadiazole, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C6H3BrN2S
To a flask equipped with a reflux device, 2.7 g (24.2 mmol) of t-butoxypotassium, 0.3 g (0.4 mmol) of a Pd catalyst (PEPPSI?-IPr), 70 mL of toluene, 4.3 g (20.2 mmol) of the compound (b), and 1.8 mL (22.2 mmol) of pyrrolidine were added, and it was refluxed at 120¡ã C. for three hours under a nitrogen atmosphere. After a reaction was finished, solids in a reaction solution were removed by filtration, the filtrate was condensed, and then refinement was performed by column chromatography using dichloromethane as a developing solution, to thereby obtain a compound (c2) (2.9 g, 14 mmol, yield: 70percent).
The synthetic route of 22034-13-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AGC Inc.; MIYAKE, Noriaki; Okada, Satoshi; Irisawa, Jun; Konishi, Teppei; Matsuura, Keigo; US2018/346729; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary