Some common heterocyclic compound, 626-88-0, name is 1-Bromo-4-methylpentane, molecular formula is C6H13Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 1-Bromo-4-methylpentane
General procedure: The solution of dihydroxyacetophenone (1, 1.0equiv), anhydrous potassium carbonate (2.0equiv) and corresponding alkyl bromides (2, 1.1equiv) in acetonitrile was stirred at 70-80C for 4-5h. After evaporation of acetonitrile, the reaction mixture was diluted with dichloromethane and washed with water three times. The organic layer was dried with anhydrous sodium sulfate and evaporated under reduced pressure. The crude product was purified by column chromatography to give 3. 6.1.1.2 1-(2-Hydroxy-6-(4-methylpentyloxy)phenyl)ethanone (3b) Yield 45%; light green liquid; Rf 0.60 (1:9 EA: HX); IR (KBr) 3335, 2917, 2850, 1618 cm-1; 1H NMR (CDCl3) delta 13.26 (s, 1H), 7.31 (t, J = 8.2 Hz, 1H), 6.54 (dd, J = 0.8, 8.4 Hz, 1H), 6.36 (d, J = 8.2 Hz, 1H), 4.01 (t, J = 6.5 Hz, 2H), 2.70 (s, 3H), 1.92-1.85 (m, 2H), 1.58-1.51 (m, 1H), 1.38-1.31 (m, 2H) 0.84 (d, J = 6.5 Hz, 6H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 626-88-0, its application will become more common.
Reference:
Article; Venkateswararao, Eeda; Sharma, Vinay K.; Yun, Jieun; Kim, Youngsoo; Jung, Sang-Hun; Bioorganic and Medicinal Chemistry; vol. 22; 13; (2014); p. 3386 – 3392;,
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bromide – Wiktionary