In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4766-33-0 as follows. Safety of 5-Bromonaphthalen-1-amine
General procedure: To a stirred solution of 3-chloro-6-nitrobenzo[d]isothiazole 1,1-dioxide (2) 1 mmol) in THF (15 mL), triethylamine (3 mmol) and aromatic amine (1 mmol) were added. The mixture was stirred at room temperature for 4~6 h. The solvent was eliminated in vacuo and the resulting residual was recrystallised from ethyl acetate/hexane to give the title compounds in mediate to high over yield.
According to the analysis of related databases, 4766-33-0, the application of this compound in the production field has become more and more popular.
Reference:
Article; Shang, Erchang; Wu, Yiran; Liu, Pei; Liu, Ying; Zhu, Wei; Deng, Xiaobing; He, Chong; He, Shan; Li, Cong; Lai, Luhua; Bioorganic and Medicinal Chemistry Letters; vol. 24; 12; (2014); p. 2764 – 2767;,
Bromide – Wikipedia,
bromide – Wiktionary