Month: February 2021

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4333-56-6 as follows. Product Details of 4333-56-6

To a stirred solution of cyclopropyl bromide (4.0 mL, 50 mmol) in 120 mL of ether at-78C was added dropwise a 1.7M solution of t-butyllithium in pentane (44.5 mL, 75.7 mmol). After 10 min, cooling bath was removed, stirring was continued for 1.5 h. The mixture was cooled again in a-78C bath, and 3-furaldehyde (3.5 mL, 41.9 mmol) was added. Reaction was continued for 1 h, and quenched with a saturated NH4CI aqueous solution. The aqueous mixture was extracted with CH2CI2 (100 mL x 3). The organic extracts were washed with brine, dried by Na2SO4, filtered, and concentrated in vacuo to give 5.3 g (91 %) of the alcohol product as a yellow oil.

According to the analysis of related databases, 4333-56-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2005/68460; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 445-02-3, name is 4-Bromo-2-(trifluoromethyl)aniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 445-02-3, Recommanded Product: 4-Bromo-2-(trifluoromethyl)aniline

EXAMPLE 19 (E)-3-Cyclopentyl-2-[4-(5-methyl-tetrazol-1-yl)-3-trifluoromethyl-phenyl]-N-thiazol-2-yl-acrylamide A solution of 2-(trifluoromethyl)-4-bromoaniline (4.8 g, 20 mmol) in dry tetrahydrofuran (20 mL) was cooled to 0 C. and then treated with acetic anhydride (8.2 g, 80 mmol). The reaction mixture was stirred at 0 C. for 10 min and then allowed to warm to 25 C. The reaction mixture was stirred at 25 C. for 2 h, at which time, thin layer chromatography analysis of the reaction mixture indicated the absence of starting material. The reaction mixture was then concentrated in vacuo. The crude residue precipitated from diethyl ether (50 mL) and hexanes (50 mL). The solid was collected by filtrated and washed with hexanes to afford N-(4-bromo-2-trifluoromethyl-phenyl)-acetamide (5.07 g, 90%) as an amorphous white solid: EI-HRMS m/e calcd for C9H7BrF3NO (M+) 281.8352, found 281.8348.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Sidduri, Achyutharao; US2002/35266; (2002); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 202865-83-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 202865-83-6, name is 1-Bromo-3-fluoro-5-methylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To an oven-dried 5 mL screw-capped vial, N-(5-chloroquinolin-8-yl)butyramide (1a) (75 mg, 0.3mmol), heptafluoroisopropyl iodide (178 mg, 0.60 mmol), Pd(OAc)2 (6.7 mg, 0.03 mmol),1-AdCOOH (10.8 mg, 0.06 mmol), K2CO3 (124 mg, 0.9 mmol), toluene (276 mg, 3.0 mmol) andchlorobenzene (0.7 mL) were added in a glove box. The mixture was stirred for 48 h at 140 Cfollowed by cooling. The resulting mixture was filtered through a celite pad and concentrated invacuo. The residue was purified by column chromatography on silica gel (eluent: hexane/EtOAc=2/1) to afford the desired alkylated product 2a (61 mg, 60%) as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3-fluoro-5-methylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kubo, Teruhiko; Aihara, Yoshinori; Chatani, Naoto; Chemistry Letters; vol. 44; 10; (2015); p. 1365 – 1367;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 2862-39-7, The chemical industry reduces the impact on the environment during synthesis 2862-39-7, name is 2-Bromo-N,N-dimethylethanamine hydrobromide, I believe this compound will play a more active role in future production and life.

50 ml of N,N-dimethylformamide and 7.37 g of dimethylaminobromoethane hydrobromide were added to the reaction vessel.(0 ¡¤ 0318 mol), adding 5 g of potassium carbonate, stirring at room temperature for 15 min, adding 4.5 g of 2-benzylpyridine (0.0265 mol), heating to 80 C for 5 h, monitoring by TLC, filtering while hot, adding 150 ml of water and 150 ml of filtrate. Extracted with ethyl acetate and extracted with 100 ml of ethyl acetate.The ethyl acetate phases were combined and concentrated to give 6 g of Pheniramine.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-N,N-dimethylethanamine hydrobromide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangdong Zhongsheng Pharmaceutical Co., Ltd.; Guangdong Xian Qiang Pharmaceutical Co., Ltd.; Tan Zhenyou; Deng Jun; CN108164455; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 955959-84-9, These common heterocyclic compound, 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

0.21 g of palladium(II) acetate, xylene (20 mL), and 0.76 g of tri-tert-butylphosphine are added,Stirred at 60 ¡ãC for 30 minutes.The above solution was added to a flask heated to 60¡ãC under nitrogen to give the above compound 2 (7,9-Dihydrobenzo[4,5]furo[2,3-g]benzofurano[2′,3′:4,5]indolo[2,3-b]carbazole 7.4g), 4-(4-Bromophenyl)dibenzo[b,d]furan (13.2 g) and sodium tert-butoxide 5.2 g (54 mmol) were added to the above solution together with xylene (180 mL). Then, it heated up at 130 ¡ãC, and it heat-stirred for 6 hours. After cooling to room temperature, 200 mL of water was added. After the organic layer was extracted with chloroform, the organic layer was dried over MgSO 4 , the solvent was removed, and silica gel column chromatography was performed to give Compound A-9 (7.4 g, 47percent).

The synthetic route of 955959-84-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Co., Ltd. LG Chemical; Hong Wanshao; He Zaicheng; Xu Shangde; Jin Zhengfan; Li Zaizhuo; Jin Yuanhuan; (73 pag.)CN108017654; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 2635-13-4, name is 5-Bromobenzo[d][1,3]dioxole, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2635-13-4, Product Details of 2635-13-4

Step 1a. 5-Bromo-6-iodobenzo[d][1,3]dioxole (Compound 0102-1) A solution of 5-bromobenzo[d][1,3]dioxole (10.0 g, 50.0 mmol), anhydrous acetonitrile (150 mL), TFA (11.4 g, 100.0 mmol) and NIS (33.7 g, 150.0 mmol) was stirred at room temperature for 24 h. The solvent was removed under reduce pressure and the crude purified by column chromatography on silica gel (petroleum) to yield the title compound 0107-1 as a white solid (18.5 g, 91%): 1H NMR (DMSO-d6) delta 5.99 (s, 2H), 7.10 (s, 1H), 7.26 (s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromobenzo[d][1,3]dioxole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Cai, Xiong; Qian, Changgeng; US2010/184801; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4549-33-1, name is 1,9-Dibromononane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C9H18Br2

General procedure: To a stirred solution of 2-(phenylsulfonyl)methyl-4,5-diphenyloxazole 1 (500 mg, 1.33 mmol, 1.0 equiv) in dry THF (10 mL) was added potassium tert-butoxide (1.60 mmol, 1.2 equiv) at 5 C. The resulting yellow reaction mixture was stirred under a nitrogen atmosphere (30 min). The dibromo alkane (1.60 mmol, 1.2 equiv) was then slowly added to the reaction mixture by syringe, and reaction mixture was allowed to warm to room temperature and stirring was continued (16 h). After completion of reaction, cold water (10 mL) was poured into the reaction mixture followed by extraction with dichloromethane (2 x 20 mL). The organic layers were combined, washed with brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude residue was submitted to gravity-column chromatography (hexane/ethyl acetate, 9:1) to afford the corresponding products 2a-d.

The synthetic route of 4549-33-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Patil, Pravin C.; Luzzio, Frederick A.; Tetrahedron; vol. 73; 29; (2017); p. 4206 – 4213;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 203302-95-8, name is 4-Bromo-3,5-difluoroaniline, This compound has unique chemical properties. The synthetic route is as follows., category: bromides-buliding-blocks

4-bromo-3, 5-difluoroaniline (500 mg, 2.4 mmol), 2-trifluoromethoxybenzeneboronic acid (590 mg, 2.9 mmol), Pd2(dppf)Cl2 (98 mg, 0.12 mmol), cesium carbonate (2.35 g, 7.2 mmol) and acetonitrile/water (10 mL/1 mL) were added to a microwave tube. The mixture was nitrogen sparged for 5 min, stirred and heated to 120 C for 1 hour under microwave, washed with saturated ammonium chloride (20 mL), and separated by silica gel column (petroleum ether: ethyl acetate = 50:1) to give the product of 2,6-difluoro-2?-trifluoromethoxy-[1,1?-biphenylyl]-4-amine (yellow oil, 460 mg), with a yield of 66.3%. 1H NMR (400 MHz, CDCl3) delta 7.47-7.28 (m, 4H), 6.29-6.27 (d, J= 9.1Hz, 2H), 3.67 (s, 2H). MS (ESI) m/z: 290.1 (MH+).

According to the analysis of related databases, 203302-95-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Fudan University; WANG, Yonghui; HUANG, Yafei; YU, Fazhi; TANG, Ting; EP3476829; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 113170-72-2, A common heterocyclic compound, 113170-72-2, name is 3-Bromo-5-(trifluoromethyl)benzene-1,2-diamine, molecular formula is C7H6BrF3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 8 : 7-brom -2-(6-fluoropyridin-3 -yl)-5 -(trifluoromethyl)- 1 H-benzimidazole To a mixture of 6-fluoronicotinaldehyde (2.5 g, 19.98 mmol), 3-bromo-5-(trifluoromethyl)benzene-l,2-diamine (4.84 g, 19.98 mmol) in DMF (40 ml) and water (4 ml) added potassium peroxymonosulfate (7.99 g, 12.99 mmol) in portions over 1 hour. The reaction mixture was stirred overnight under N2 then pour into water (50 ml), extract with 3×80 ml ethyl acetate. The organic layers were combined, washed with 2×25 ml of saturated brine, dried over anhydrous sodium sulfate and concentrated under vacuum. Part of the product was crystallized from dichloromethane. The mother liquor was purified by reverse phase HPLC to afford 7- bromo-2-(6-fluoropyridin-3-yl)-5 -(trifluoromethyl)- 1 H-benzimidazole as brown solid. LC-MS (ES, m/z) Ci3H6BrF4N3 : 361; Found: 362 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; INTERVET INTERNATIONAL B.V.; DE VITA, Robert, J.; HONG, QingMei; LAI, Zhong; DYKSTRA, Kevin, D.; YU, Yang; LIU, Jian; SPERBECK, Donald; JIAN, Tianying; GUIADEEN, Deodial; XU-QIANG YANG, Ginger; WU, Zhicai; HE, Shuwen; TING, Pauline, C.; ASLANIAN, Robert; KUETHE, Jeffrey, T.; BALKOVEC, James, M.; KUANG, Rongze; ZHOU, Gang; WU, Heping; WO2012/164071; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 393-37-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 393-37-3 as follows.

General procedure: Example 3Tandem Borylation/Dehalogenation of 1-Chloro-4-fluoro-3-Substituted- and 1-Bromo-4-fluoro-3-Substituted BenzenesTandem borylation/dehalogenation was also investigated as a strategy for the ortho-borylation of arenes that are substituted with an electron-withdrawing group. The scheme below illustrates the tandem borylation/dehalogenation methodology which was investigated. As discussed above, in the case of arenes that are substituted with an electron-withdrawing group, iridium-catalyzed C-H activation-borylation of the arene is typically governed by steric effects. In tandem borylation/dehalogenation, the substrate can include an electron-withdrawing group and a sacrificial atom (e.g., a halogen such as Cl or Br) positioned para to the electron-withdrawing group, so as to sterically hinder attack of the iridium catalyst at the otherwise sterically favored position meta to the electron-withdrawing group. As a result, iridium-catalyzed C-H activation-borylation of the arene exclusively generates the ortho-borylated (electronic) product. Subsequent dehalogenation can afford exclusively the desired electronic product.[0337] General Procedure for Borylation [0338] In a nitrogen atmosphere glovebox B2Pin2 (140 mg, 0.55 mmol) was weighed into a 20 mL vial containing a magnetic stir bar. [Ir(OMe)cod]2 (6.6 mg, 0.02 mmol) and 4,4?-di-tert-butyl-2,2?-dipyridyl ligand (5.4 mg, 0.02 mmol) were weighed into two separate test tubes, each being diluted with THF (2 mL). The [Ir(OMe)cod]2 solution was transferred into the 20 mL vial containing B2Pin2. This mixture was stirred until a golden yellow clear solution was obtained. The solution containing ligand was transferred into the vial, and the mixture was stirred until it became a dark brown color solution. The substrate (1 mmol) was added to the vial, which was then sealed. The reaction mixture stirred for 24 h at rt, after which the vial was removed from the glovebox. The reaction mixture was passed through a short plug of silica eluting with a 10:1 hexane/EtOAc solution (2¡Á10 mL). The volatiles were removed by rotary evaporation affording the product, which was characterized using standard methodologies. 4-Bromo-1-fluoro-2-(trifluoromethyl)benzene was borylated using the general procedure described above. The borylation reaction afforded product as colorless oil (0.229 g, 62%): 1H NMR (500 MHz, CDCl3) delta 8.02 (dd, J=2.5, 3.5 Hz, 1H), 7.78 (dd, J=2.5, 6.5 Hz, 1H), 1.36 (s, 12H); 13C NMR (125 MHz, CDCl3) delta 162.9 (dd, J=1.9, 259.7 Hz), 143.1 (d, J=8.5 Hz), 132.8 (qd, J=1.9, 4.7 Hz), 121.7 (q, J=270.3 Hz), 120.0 (qd, J=33.1, 16.1, Hz), 116.3 (d, J=3.5 Hz), 84.7, 24.8; 19F NMR (470 MHz, CDCl3) delta 61.9, 106.4; 11B NMR (160 MHz, CDCl3) delta 29.3 (br s).

According to the analysis of related databases, 393-37-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Smith, III, Milton R.; Maleczka, JR., Robert E.; Li, Hao; Jayasundara, Chathurika; Oppenheimer, Jossian; Sabasovs, Dmitrijs; US2015/65743; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary