Synthetic Route of 327-51-5, These common heterocyclic compound, 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 1 , 4-dibromobenzene (4.4 g, 16.3 mmol) , 2-(tributylstannyl)pyrimidine (3.0 g, 8.13 mmol), copper (I) iodide (154 mg, 0.81 mmol) in toluene (50 ml) were purged with nitrogen for 15 min.Tetrakis(thphenylphosphine)palladium(0) (939 mg, 0.81 mmol) was added and the mixture was stirred at 110 C in a sealed-tube for 1 day. The mixture was cooled to r.t. and was diluted with water and ethyl acetate. Layers were separated. The separated organic layer was dried (MgSO4), filtered and solvents were removed in vacuum. Column purification [Hexanes – Ethyl acetate, 2:1 (v/v)] gave bromide 2AD (1.09 g, 50%) as white solid.
The synthetic route of 327-51-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SCHERING CORPORATION; WO2008/156739; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary