These common heterocyclic compound, 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: bromides-buliding-blocks
Add 1,4-dibromo-2,5-difluorobenzene (1.09 g, 4 mmol), phenylboronic acid (1.21 g, 10 mmol), tetrakis(triphenylphosphine)palladium(0) (468 mg, 0.4 mmol) THF (50 mL) and aqueous potassium carbonate (1M, 20 mL) were then evaporated and then th After cooling to room temperature, the layers were separated. The aqueous phase was extracted with dichloromethane (3¡Á50 mL). The residue was purified by silica gel column was using dichloromethane: hexane (1: 5) as eluent to give the product as a white solid (0.82g, 77.1%);
The synthetic route of 1,4-Dibromo-2,5-difluorobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shandong Normal University; Ren Xiuhui; Zhu Fucheng; Zhang Xi; Geng Yan; (23 pag.)CN110003179; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary