In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 399-94-0, name is 1-Bromo-2,5-difluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 399-94-0
2,5-difluorobromobenzene (15.05g, 78mmol) was dissolved in dry toluene (50mL) under nitrogen, and the ice salt bath was cooled to below -10 C. Isopropylmagnesium chloride/lithium chloride tetrahydrofuran solution was added dropwise. (66 mL, 1.3 mol/L), kept stirring at about -10 C for 1 hour.1D (10 g, 39 mmol) was dissolved in dry tetrahydrofuran (100 mL).Add dropwise to the above reaction solution, keep the temperature below -10 C, add,The reaction was carried out for 4 hours at room temperature. Lower the temperature below -10 C,Saturated ammonium chloride solution (40 mL) was added dropwise and stirred for 10 minutes.Adjust the pH to 5-6 with a 3 mol/L hydrochloric acid solution, and let stand for stratification.The aqueous phase was extracted with methyl tert-butyl ether (50 mL¡Á2) and the organic phases were combined.Wash with a saturated sodium chloride solution (30 mL ¡Á 2), and dry over anhydrous sodium sulfate.Filtration, concentration, column chromatography (petroleum ether / ethyl acetate (v / v) = 50:1-8:1),A pale yellow solid 1E (10.1 g, yield 83.5%) was obtained.
The synthetic route of 399-94-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sichuan Hai Sike Pharmaceutical Co., Ltd.; Fan Jiang; Feng Jianchuan; Peng Fei; Chen Qingping; (45 pag.)CN105085530; (2019); B;,
Bromide – Wikipedia,
bromide – Wiktionary