Related Products of 656-64-4,Some common heterocyclic compound, 656-64-4, name is 3-Bromo-4-fluoroaniline, molecular formula is C6H5BrFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 3 (80g, 0.4923mo1), compound 4 (280g, 1.474 mol) and ethanol (2.4L) were added into the reactor, then the reactor was heated to reflux for 1 hours, then the mixture was concentrated, and the crude product was washed with n-hexane/ethyl acetate (200mL, V/V=10: 1) , filtered, dried to obtain compound 5(138g, yield 88.7%).MS: 316 [M+lfb. ?H-NMR(400Hz, DMSO-d6): 11.42 (s, 1 H), 8.86 (s, 1 H), 7.17 (dd, 1 H), 7.08 (dd, 1H), 6.77 – 6.71 (m, 1 H), 6.24 (s, 2 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromo-4-fluoroaniline, its application will become more common.
Reference:
Patent; XU, Yong; HUANG, Lu; (26 pag.)WO2017/124822; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary