Adding a certain compound to certain chemical reactions, such as: 4333-56-6, name is Bromocyclopropane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4333-56-6, Application In Synthesis of Bromocyclopropane
Dissolve 4-bromo-benzenethiol (2.00 g, 10.6 mmol) in dry DMSO (50 mL) under a nitrogen atmosphere. Add potassium tert-butoxide (1. 30 g, 11.7 mmol) and stir until dissolved. Add cyclopropyl bromide (2.6 mL, 31.8 mmol) and heat the reaction to 80 C for 2 days. Cool to room temperature and pour the reaction into water (500 mL). Extract the aqueous layer with Et20 (2 x 200 mL) and wash the combined organic layers with water (100 mL). Dry over sodium sulfate and concentrate in vacuo. Chromatograph the residue on a Si02 column eluting the material with hexanes to give 1.73 g of 1-bromo-4- cyclopropylsulfanyl-benzene (72%). Dissolve l-bromo-4-cyclopropylsulfanyl-benzene (1.73 g, 7.55 mmol) in dry methylene chloride (75 mL). Slowly add mCPBA (4.8 g, 18. 8 mmol, 68%) in portions to control a mild exotherm. After stirring for 1 hour, filter the resultant precipitate. Wash the filtrate with IN NaOH (50 mL) and dry the organic layer with sodium sulfate. Concentrate in vacuo to yield 2.0 g of 1-bromo-4-cyclopropanesulfonyl-benzene (100%). Dissolve l-bromo-4-cyclopropanesulfonyl-benzene (500 mg, 1.91 mmol), bis (pinacolato) diboron (577 mg, 2.29 mmol), potassium acetate (513 mg, 5.70 mmol) and PdCl2 (dppf) CH2C12 (46 mg, 0.057 mmol) in dry DMSO (10 mL) under a nitrogen atmosphere. Heat the mixture to 80C for four hours. Cool the reaction to room temperature and pour into water (100 mL). Extract the aqueous phase with Et20 (2 x 50 mL) and wash the combined organic layers with water (50 mL). Dry over sodium sulfate and concentrate in vacuo. Chromatograph the residue on a Si02 column eluting the material with EtOAc in hexanes (10 to 40%) to give 200 mg of the title compound (34%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Bromocyclopropane, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ELI LILLY AND COMPANY; WO2004/9086; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary