Related Products of 138526-69-9, These common heterocyclic compound, 138526-69-9, name is 1-Bromo-3,4,5-trifluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Argon gas protection 1000ml three-necked bottle, add cyclobutene benzoic acid 60g,77 g of 3,4,5-trifluorobromobenzene was added, and 5 g of tetrabutylammonium bromide was added.188 g of absolute ethanol was added, stirred until fully dissolved, and the temperature was raised to 40 C, and 0.6 g of a palladium chloride catalyst was added.Continue to heat up to 68 ~ 72 C weak reflux,Temperature control 68 ~ 72 C drop added Sodium carbonate 100g / water 200g solution,After the dropwise addition, the reaction was kept at this temperature for 4 h, the reaction was stopped, 200 g of toluene was added, and 200 g of water was added.Stir for 2h, separate the liquid, wash to neutral, dry, filter, and concentrate to obtain the product.GC analysis content >95%, yield >98%.
The synthetic route of 138526-69-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shandong Shenghua Science And Technology Chuangyeyuan Co., Ltd.; Wu Shengxi; Liu Yuyang; Wang Dexian; Du Kaichang; Gao Genhua; (10 pag.)CN108178720; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary