Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 103-64-0, name is (2-Bromovinyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., category: bromides-buliding-blocks
At room temperature,To the appropriate amount of the organic solvent DMF was added 100 mmol of the compound of the above formula (I)220 mmol of the compound of formula (II)6 mmol of catalyst (2.4 mmol of Pd (TFA) 2 with 3.6 mmol of Cu (acac) 2)50 mmol of 1-ethyl ethyl ether-3-methylimidazolebis (trifluoromethanesulfonyl) imide and 300 mmol of triisopropanolamine,Then heated to 80 C,And the reaction was stirred at that temperature for 6 hours; After the reaction,The resulting mixture was filtered while hot,To obtain a filtrate;To the filtrate was added a 10% hydrochloric acid solution with a mass percentage of 10%Adjust the pH to neutral;Then ethyl acetate,Oscillation extraction 2-3 times,Combined organic phase,Dried over anhydrous magnesium sulfate,Then concentrated under reduced pressure,The resulting residue was subjected to 200-300 mesh silica gel column chromatography,The petroleum ether-n-butanol mixture was used as the eluent,Wherein the volume ratio of petroleum ether to n-butanol is 10: 1,Thereby obtaining a compound of the above formula (III)The yield was 97.4%.
According to the analysis of related databases, 103-64-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Qingdao University; Xia Yunqiu; Zhou Yingbin; Wang Yanxin; Zhong Weizhen; Guo Shenbo; (9 pag.)CN104803912; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary