Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 103273-01-4, name is 2-Bromo-4-(tert-butyl)aniline, This compound has unique chemical properties. The synthetic route is as follows., Safety of 2-Bromo-4-(tert-butyl)aniline
Prepared according to a modified literature procedure.14 To a solution of 2-bromo-4-(tert-butyl)aniline (11) (684 mg, 3.00 mmol, 1.0 eq.) in acetonitrile (6 mL) at room temperature, was added methyl acrylate (675 muL, 7.50 mmol, 2.5 eq.), palladium acetate (135 mg, 0.6 mmol, 20 mol %), tri-o-tolylphosphine (640 mg, 2.10 mmol, 0.7 eq.) and triethylamine (1.67 mL, 12.0 mmol, 4.0 eq.).The reaction was heated to reflux for 9 hours, cooled to room temperature and concentrated under reduced pressure. The crude residue was dissolved in ethyl acetate, washed with water and the aqueous phase extracted with ethyl acetate. The combined organic phases were dried over magnesium sulphate and the solvent removed under reduced pressure. Purification by flash chromatography on silica gel (SiO2, petroleum ether 30-40: EtOAc 9:1-4:1) afforded the title compound as a yellow solid (531 mg, 2.28 mmol, 76 % yield).
According to the analysis of related databases, 103273-01-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Buckingham, Faye; Calderwood, Samuel; Checa, Begona; Keller, Thomas; Tredwell, Matthew; Collier, Thomas Lee; Newington, Ian M.; Bhalla, Rajiv; Glaser, Matthias; Gouverneur, Veronique; Journal of Fluorine Chemistry; vol. 180; (2015); p. 33 – 39;,
Bromide – Wikipedia,
bromide – Wiktionary