Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7745-91-7, name is 3-Bromo-4-methylaniline, A new synthetic method of this compound is introduced below., Recommanded Product: 7745-91-7
Aniline 4 (20.0 g, 107 mmol) was added to 30 mL of H2O and the mixture wasstirred vigorously with mechanical stirring as concentrated HCl (30 mL) was added slowly.A thick white solid formed immediately upon the addition of the acid. The mixture wascooled to -15 to -25C using a dry ice/acetone bath. A solution of NaNO2 (9.65 g, 140mmol) in H2O (30 mL) was added dropwise with continuous vigorous stirring to preventthe mixture from freezing. After the addition was complete, the reaction was kept cold andHBF4 (27 mL, 215 mmol, 48% in H2O) was added dropwise. A white solid (5) formedthat was vacuum filtered and washed with cold H2O and cold MeOH. The resultingproduct was dried under high vacuum overnight to give the fluoroborate salt as a whitesolid (28.1 g, 99 mmol, 92%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Bohen, Alyssa A.; Mullane, Kimberly C.; Bohen, Joseph M.; Mallory, Clelia W.; Mallory, Frank B.; Tetrahedron Letters; vol. 56; 23; (2015); p. 3342 – 3345;,
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