Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57946-63-1, name is 2-Bromo-4-(trifluoromethyl)aniline, This compound has unique chemical properties. The synthetic route is as follows., name: 2-Bromo-4-(trifluoromethyl)aniline
To a 100-mLround-bottom flask was placed a solution of 2-bromo-4-(trifluoromethyl)aniline (4.8 g,20.00mmol) in THF (20 mL) then DMAP (488 mg,3.99 mmol) and Boc2O (8.72 g) were added. The reaction was heated to reflux overnight then concentrated under reduced pressure. The residue was purified by column chromatography eluting with EtOAc/petroleum ether (1:50) affording 7.9 g of the title compound as a white solid. 1H NMR (300 MHz,CDCl3): oe 7.89 (s,1H ),7.62-7.59 (d,J = 9.0 Hz,1H ),7.38-7.35 (d,J = 9.0 Hz,1H ),1.42 (s,9H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 57946-63-1.
Reference:
Patent; PROTEOSTASIS THERAPEUTICS, INC.; MUNOZ, Benito; BASTOS, Cecilia, M.; PARKS, Daniel; KOMBO, David; (301 pag.)WO2017/62581; (2017); A1;,
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bromide – Wiktionary