Synthetic Route of 25462-61-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25462-61-7, name is 2,5-Dibromobenzene-1,4-diamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
In a Schienk flask, 2,5-dibromo-1,4-phenylenediamine (1 g, 3.76 mmol) and 2-(4,4,5,5-Tetramethyl-1,3,2-dioXaborolan-2-yl)-5-propylthiophene 10 (3.8 g, 15.04 mmol) were charged under the protection of nitrogen. After adding 75 ml toluene, 30 ml ethanol and 20 ml Cs2CO3 aqueous solution (2.0 mol/l), the mixture was degassed for 45 mm. Pd(PPh3)4 (435 mg, 0.376 mmol) was added. The mixture was thenheated to 80 C, stirred overnight, poured into brine and extracted by dichloromethane for several times. The organic phase was dried over Mg2SO4 and the solvent was evaporated in vacuo. The product was purified by chromatography on silica gel (CH2CI2) to give product 11 as yellow flaky crystal (860 mg, 63%). ?H NMR (400 MHz, CDCl3,. ppm): 1.00 (t, J 7.34 Hz, 6H), 1.73 (dd, .1= 15.00, 7.44 Hz, 4H), 2.80 (t, J = 7.36 Hz, 4H), 4.27-3.02 (br, 2H), 6.76 (m, 4H),7.02 (d, J = 1.96 Hz, 2H). 13C NMR (100 MHz, CDCl3, ppm): 145.9, 138.4, 136.2,125.8, 124.8, 121.9, 118.5, 32.4, 25.1, 14.0.
The synthetic route of 2,5-Dibromobenzene-1,4-diamine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK PATENT GMBH; ZHANG, Fan; WANG, Xinyang; TANG, Ruizhi; FU, Yubin; ZHUANG, Xiaodong; FENG, Xinliang; WU, Dongqing; WO2015/43722; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary