In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 58971-11-2, name is 3-Bromophenethylamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 3-Bromophenethylamine
Synthesis of 2-[3-(4,4,5,5-Tetramethyl-[l,3,2] dioxaborolan-2-yl)-phenyI]-ethyIamine; To a solution of 2-(3-bromo-phenyl)-ethylarnine (500 mg, 2.5 mmol) and 4,4, 5,5,4′ ,4′,5′,5′- octamethyl-[232′]bi[[l,3,2]dioxaborolanyl] (1.9 g, 7.5 mmol) in N, N-dimethylformamide (5.0 mL) was added potassium acetate (1.23 g, 12.5 mmol) and [1,1′- bis(diphenylphosphino)ferrocene]dichloropalladium(II) (185 mg, 0.250 mmol) and the solution was heated at 80 0C overnight. The solution was filtered through a plug of silica, washed with dichloromethane and the solvent was concentrated to afford the crude 2-[3- (4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2-yl)-phenyl]-ethylamine. The crude material was carried on without further purification.
The synthetic route of 58971-11-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2007/76247; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary