These common heterocyclic compound, 38573-88-5, name is 1-Bromo-2,3-difluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 38573-88-5
Example 33 [0128] (4-(2-(2, 3-DIFLUOROPHENYL) ETHYNYL)-1-BOC-PYRROL-2-YL) (PYRROLIDIN-1- yl) methanone. A mixture of (4-ethynyl)-1-BOC-pyrrol-2-yl) (pyrrolidin-1-yl) methanone (4 g, 13. 88 mmol), 2, 3-DIFLUORO-1-BROMOBENZENE (4 g, 20.8 mmol), PDCL2PPH2 (0.97 g, 1. 38 mmol) and Cul (0.53 g, 2.76 mmol in trietylamine (40 ML) was stirred at room temperature for 4 hr. The solid was filtered and washed with ethyl acetate (100 mL). The filtrate was washed with 2N HC1 (3x 100 mL), brine (100 mL) and water (100 mL). The organic layer was dried and concentrated under reduced pressure. The crude product was purified by Biotage HPFC system (40-65percent EtOAC/Hexane) to afford title as a dark brown oil (1.35 g, 24percent).
The synthetic route of 1-Bromo-2,3-difluorobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; LI, Pan; TOMLINSON, Ronald, C.; WO2005/16920; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary