Electric Literature of 766-81-4,Some common heterocyclic compound, 766-81-4, name is 3-Bromophenylacetylene, molecular formula is C8H5Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under a nitrogen atmosphere,In a 5 mL reaction tube with a Teflon magnetic stir bar,Add 0.015 mmol of cuprous iodide, 0.0075 mmol of 4,4′-di-tert-butyl-2,2′-bipyridine,6.0 mmol of tetrahydrofuran, 3.9 mmol of n-hexane,0.30 mmol 2-chlorophenylacetylene, 0.36 mmol (2-azidoethyl)benzene,0.39 mmol of pentafluoropropionic anhydride, and finally 0.45 mmol of triethylamine,Stir the reaction in a closed system for 15 h at 40 C in an oil bath and then cool to room temperature.Using trifluoromethoxybenzene as an internal standard, the 19F yield was greater than 99%.The organic phases were combined, filtered through 100-200 mesh silica gel and rinsed with dichloromethane.The organic solvent was removed by rotary evaporation to give a crude material.Eluted with n-pentane and dichloromethane (1:1, v/v),6-(2-Chlorophenyl)-3-(pentafluoroethyl)-4-phenylethyl-1,2,4-triazin-5(4H)-one (yield 99%) was obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromophenylacetylene, its application will become more common.
Reference:
Patent; Fuzhou University; Weng Zhiqiang; Wu Wei; (22 pag.)CN109111406; (2019); A;,
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