Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 41459-42-1, Name is 3-Bromo-2-(bromomethyl)propanoic acid, SMILES is O=C(O)C(CBr)CBr, in an article , author is Mahmood, R., once mentioned of 41459-42-1, Application In Synthesis of 3-Bromo-2-(bromomethyl)propanoic acid.
Effect of vitamin A as a neoadjuvant agent in chemotherapy and photodynamic therapy of Rhabdomyosarcoma cells
Combinational therapy is among the most used treatment modality’s to increase cancer treatment efficacy. It may also reduce side effects, treatment time, and development of drug resistance. The effects of different analogues of vitamin A (VA) as neoadjuvant agent were observed in this study with chemotherapeutic drugs (doxorubicin and methotrexate) and photodynamic therapy (PDT) using 5-ALA and Photogem as photosensitizers in RD cells. The uptake time of photosensitizer was optimized by means of spectrophotometric measurements. Diode laser (lambda = 635 nm +/- 1 nm) was used as an illumination source for PDT. Responses of administered drugs were assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. VA and its analogues exert prophylactic and therapeutic effects. Protective or antagonistic effects (CI > 1) were observed in each of the case. These results propose that the use of VA as a neoadjuvant agent in combinational therapeutic modalities may reduce the efficacy of cancer treatment protocols as well as the existing side effects. Thus, VA is not the successful drug for combinational therapies and under treatment cancer patients should try to avoid its use with oxidative stress induction therapies (e.g. PDT, Radiotherapy, chemotherapy).
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 41459-42-1, you can contact me at any time and look forward to more communication. Application In Synthesis of 3-Bromo-2-(bromomethyl)propanoic acid.