Month: April 2021

Synthetic Route of 129316-09-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 129316-09-2, Name is 1,3-Dibromo-5-(tert-butyl)benzene, SMILES is CC(C)(C)C1=CC(Br)=CC(Br)=C1, belongs to bromides-buliding-blocks compound. In a article, author is Hou, Yong-Qiang, introduce new discover of the category.

Multifaceted anti-colorectal tumor effect of digoxin on HCT8 and SW620 cells in vitro

Background: Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. Novel drugs for CRC therapy are urgently needed. Digoxin has been in clinical use for treatment of heart failure and atrial arrhythmias for many years. Fragmentary reports suggested that digoxin might have antitumor efficacy on CRC. Here, we aimed to investigate the antitumor effect of digoxin on human CRC cells and the underlying mechanism. Methods: Cell viability was determined using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay and plate colony formation assay. The effects of digoxin on cell-cycle distribution and apoptosis were analysed by flow cytometry. The anti-metastatic effect on tumor cells was determined by wound-healing assay and transwell assay. Anti-angiogenic effect was examined by determining the inhibition against proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs). Mechanism study was performed by Western blot, enzyme-linked immunosorbent assay (ELISA), and gelatin-zymography assay. Results: Digoxin potently inhibited cell proliferation, induced G1-phase and G2/M-phase arrest in colorectal-cancer HCT8 and SW620 cells, respectively. No obvious apoptosis was observed in the treated cells. Anti-metastatic activities were shown on HCT8 cells by inhibiting the migration and invasion. Meanwhile, the expression of MMP2, MMP9, and phosphorylated Integrin beta 1 were decreased. Digoxin inhibited the proliferation, migration, and tube formation of HUVECs and reduced HIF1 alpha expression and vascular endothelial growth factor A (VEGF-A) secretion in HCT8 cells, suggesting anti-angiogenic activity. Furthermore, digoxin significantly reversed ABCB1-mediated multidrug resistance on SW620/Ad300 cells. Conclusion: Our findings suggest that digoxin has the potential to be applied as an antitumor drug via inhibiting proliferation and metastasis as well as reversing the ABCB1-mediated multidrug resistance of colorectal cancer.

Synthetic Route of 129316-09-2, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 129316-09-2 is helpful to your research.

Chemistry, like all the natural sciences, COA of Formula: C8H10BrN, begins with the direct observation of nature— in this case, of matter.586-77-6, Name is 4-Bromo-N,N-dimethylaniline, SMILES is C1=C(N(C)C)C=CC(=C1)Br, belongs to bromides-buliding-blocks compound. In a document, author is Tangoulis, Vassilis, introduce the new discover.

Facile Method to Prepare pH-Sensitive PEI-Functionalized Carbon Nanotubes as Rationally Designed Vehicles for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Delivery

A new pH-sensitive system designed for drug-delivery purposes and based on functionalized multiwall magnetic carbon nanotubes (Mag-CNTs) was synthesized for the effective incorporation of non-steroidal anti-inflammatory drugs (NSAIDs), aiming at drug release in characteristic acidic conditions close to the actual conditions of inflamed tissues. Cationic hyperbranched polyethyleneimine (PEI) was immobilized on the surface of Mag-CNTs via electrostatic interactions between the positively charged protonated amines within the polymer and the carboxyl groups on the chemically oxidized Mag-CNT surface. The addition of the NSAID with a carboxylate donor, Naproxen (NAP), was achieved by indirect coupling through the amino groups of the intermediate linker PEI. FT-IR, Raman, and UV-vis spectroscopy were employed to fully characterize the synthesized nanocarrier and its functionalization procedure. The interaction of the designed nanocarrier with bovine serum albumin (BSA) was studied in vitro by fluorescence emission spectroscopy while its in vitro interaction with calf-thymus (CT) DNA was monitored by UV-vis spectroscopy and viscosity measurements and via competitive studies with ethidium bromide. The calculated binding constants were compared to those of free NAP revealing a higher binding affinity for BSA and CT DNA. Finally, drug-release studies were performed, revealing that the electrostatic linkage ensures an effective release of the drug in the acidic pH typical of inflamed cells, while maintaining the multiwall nanotubes (MWNTs)-drug conjugates stable at the typical bloodstream.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 586-77-6. COA of Formula: C8H10BrN.

Reference of 506-26-3, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 506-26-3, Name is (6Z,9Z,12Z)-Octadeca-6,9,12-trienoic acid, SMILES is CCCCC/C=CC/C=CC/C=CCCCCC(O)=O, belongs to bromides-buliding-blocks compound. In a article, author is Cheng, Chao, introduce new discover of the category.

Toxicity comparison of three imidazolium bromide ionic liquids to soil microorganisms

Ionic liquids (ILs) are extensively used in several chemistry fields. And research about the effects of ILs on soil microbes is needed. In this study, brown soil was exposed to 1-butyl-3-methylimidazolium bromide ([C(4)mim]Br), 1-hexyl-3-methylimidazolium bromide ([C(6)mim]Br) and 1-decyl-3-methylimidazolium bromide ([C(10)mim]Br). The toxicities of the three ILs are evaluated by measuring the soil culturable microbial number, enzyme activity, microbial diversity and, abundance of the ammonia monooxygenase (amoA) genes of ammonia-oxidizing bacteria (AOB) and ammonia-oxidizing archaea (AOA). Results showed that all tested ILs caused a decrease in culturable microbial abundance. Tested ILs exposure inhibit urease activity and promote acid phosphatase and beta-glucosidase activities. Tested ILs reduced soil microbial diversity and the abundances of AOB-amoA and AOA-amoA genes significantly. After a comparison of the integrated biomarker response (IBR) index, the toxicities of tested ILs to soil microorganisms were as follows: [C(10)mim]Br > [C(6)mim]Br > [C(4)mim]Br. Among all collected biomarkers, the abundance of the AOA-amoA gene was the most sensitive one and was easily affected after ILs exposure. (C) 2019 Elsevier Ltd. All rights reserved.

Reference of 506-26-3, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 506-26-3 is helpful to your research.

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.1575-37-7, Name is 4-Bromobenzene-1,2-diamine, SMILES is NC1=CC=C(Br)C=C1N, belongs to bromides-buliding-blocks compound. In a document, author is Park, Sunghwan, introduce the new discover, Category: bromides-buliding-blocks.

Highly H2O permeable ionic liquid encapsulated metal-organic framework membranes for energy-efficient air-dehumidification

Isothermal membrane-based air dehumidification (IMAD) is much more energy-efficient and economical than traditional air-dehumidification technologies. There are, however, no practical IMAD process technologies currently available mainly due to limitations of current membranes. Ionic liquids (ILs) are a promising air-dehumidification membrane material. Current supported IL membranes suffer from poor stability, limiting their performances. Herein, we propose new stable IL membranes, encapsulated IL membranes (EILMs) by encapsulating 1-butyl-3-methylimidazolium bromide ([C4MIM][Br]) into ultrathin polycrystalline UiO-66-NH2 metal-organic framework membranes via a ship-in-a-bottle method. The stability of IL membranes is significantly enhanced due to the IL entrapped in the pore cages of UiO-66-NH2. The EILMs show unprecedentedly high H2O permeance (similar to 2.36 x 10(-4) mol m(-2) s(-1) Pa-1), an order of magnitude greater than that of the most permeable air-dehumidification membranes reported so far. Furthermore, the encapsulated [C4MIM][Br] drastically increases the H2O/N-2 separation factor to similar to 1560, satisfying the minimally required H2O/N-2 separation performance for commercially viable air-dehumidification.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1575-37-7 is helpful to your research. Category: bromides-buliding-blocks.

Synthetic Route of 106-37-6, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 106-37-6, Name is 1,4-Dibromobenzene, SMILES is BrC1=CC=C(Br)C=C1, belongs to bromides-buliding-blocks compound. In a article, author is Crihfield, C. L., introduce new discover of the category.

Semi-permanent cationic coating for protein separations

Capillary electrophoresis has been used extensively for protein separations, but interactions of proteins with the negative charge on the surface of fused silica capillary create band broadening and diminish the separation efficiency. Coatings developed to mask the negative charge of the capillary affect the electroosmotic flow. The method presented in this work addresses these concerns through the use of a two-layer coating of a semi-permanent phospholipid substrate and cetyltrimethylammonium bromide (CTAB). When used alone, phospholipid coating suppresses the electroosmotic flow but cannot be used to simultaneously separate anionic and cationic proteins. When used alone, CTAB creates a dynamic coating that facilitates the separation of cationic proteins with good efficiency, but reduces the separation efficiency of anionic proteins. The use of a hybrid phospholipid-CTAB surface coating alleviates protein adsorption, as demonstrated through a comparison of protein separations obtained with a bare fused silica capillary. The hybrid phospholipid-CTAB surface enables high efficiency separations of cationic and anionic proteins simultaneously. This work verifies the role of the hydrophobic tail of CTAB in developing a stable coating with an electroosmotic flow of 3.14 x 10(-4) cm(2) V-1 s(-1) (n = 10) from the cathode to the anode at a pH of 7. The coating yields a stable electroosmotic flow even after 2 h of flushing with background electrolyte devoid of CTAB (n = 3) and six consecutive protein injections with no flush sequence between runs. The coating can be used with background electrolytes with pH values ranging from 4 to 8 while maintaining 1% RSD (n = 10) in the electroosmotic flow for each background electrolyte. Six model proteins, lysozyme, ribonuclease A, alpha-chymotrypsinogen A, enolase, transferrin, and alpha-1-antitrypsin, with pI values ranging from 4.4 to 11 were used to demonstrate the stability of the phospholipid-CTAB coating, the lack of protein interaction with the wall, and the utility of the coating for the separation of proteins of similar isoelectric points and of protein isoforms. (C) 2019 Elsevier B.V. All rights reserved.

Synthetic Route of 106-37-6, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 106-37-6 is helpful to your research.

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Category: bromides-buliding-blocks, 143-15-7, Name is 1-Bromododecane, molecular formula is C12H25Br, belongs to bromides-buliding-blocks compound. In a document, author is Gossard, Alban, introduce the new discover.

High Internal Phase Emulsions Stabilized by a Zeolite-Surfactant Combination in a Composition-Dependent Manner

As a step toward synthesizing zeolite-based porous materials, this study demonstrates for the first time the feasibility of stabilizing oil-in-water (O/W) high internal phase emulsions (HIPEs) using a cationic surfactant (tetradecyltrimethylammonium bromide, TTAB) and home-made submicronic Linde type A zeolite particles. The zeolite particles are hydrophilic and therefore do not attach to dodecane-water interfaces, but surface tension measurements and electrochemical data show that their surface can be activated by the electrostatic and subsequent hydrophobic adsorption of TTAB. Comparing the adsorption isotherm of TTAB and zeta potential of the particles with the droplet sizes and rheological properties of the emulsion shows that the stabilization mechanism depends on the TTAB/zeolite weight ratio. At low TTAB/zeolite weight ratios (<= 0.2 wt %), gel-like O/W Pickering HIPEs form, but at intermediate TTAB concentrations, the zeolite particles become more hydrophobic, leading to phase inversion and the stabilization of W/O emulsions. At high TTAB/zeolite weight ratios (>1.25 wt %), a second phase inversion occurs and creamy O/W HIPEs form through a different stabilization mechanism. In this case indeed, the zeolite particles are fully covered by a bilayer of TTAB and remain dispersed in the aqueous phase with no adsorption to the dodecane-water interface. The emulsion is stabilized by electrostatic repulsion between the highly positively charged zeolite particles and the cationic surfactant adsorbed at the dodecane-water interface.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 143-15-7. Category: bromides-buliding-blocks.

Chemistry is an experimental science, HPLC of Formula: C12H25Br, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 143-15-7, Name is 1-Bromododecane, molecular formula is C12H25Br, belongs to bromides-buliding-blocks compound. In a document, author is Pal, Amalendu.

Mixed micellization behaviour of tri-substituted surface active ionic liquid and cationic surfactant in aqueous medium and salt solution: Experimental and theoretical study

The aim of the present study is to investigate the mixed micellization behaviour of trisubstituted surface active ionic liquid (SAIL) 1-tetradecyl-2,3-dimethylimidazolium bromide [C(14)bmim][Br] and cationic surfactant cetyltrimethylammonium bromide ((TAB) in aqueous solution and in the presence of inorganic salt, sodium bromide (NaBr) using the conductivity, steady-state fluorescence and H-1 NMR measurements. The degree of counter-ion dissociation (g), critical micelle concentration (cmc), various thermodynamic parameters of micellization (Delta G(m)(0), Delta H-m(0) and Delta S-m(0)) have been evaluated from conductivity measurements. All these parameters show that strong synergistic interactions have been observed in the studied mixed systems in the aqueous medium and the presence of salt promotes the electrostatic interactions that result in lowering of cmc values. The aggregation number (N-agg) of mixed micelle has been ascertained from steady-state fluorescence quenching indicate that the contribution of CTAB was always more than that of SAIL. The results have been analysed on the basis of Rubingh, Clint and Motomura theory. Various mixed micellar parameters such as ideal cmc (cmc*), activity coefficients (f(1) and f(2)), micellar mole fraction of CTAB in mixed and ideal state (X(1)(m)and X-1(ideal)), interaction parameter (beta(m)) and excess Gibbs free energy of micellization (Delta G(ex)) have been calculated at temperatures of (298.15, 308.15 and 318.15) K. Mixed micellar parameters (cmc*, X-1(m), and Delta G(ex)) reveal non-ideal behaviour of the mixed system and magnitude of interaction parameter (beta(m)) becomes more negative in the presence of salt. H-1 NMR shed light on the electrostatic interactions between CTAB and SAIL in mixed state. (C) 2019 Elsevier B.V. All rights reserved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 143-15-7. HPLC of Formula: C12H25Br.

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , HPLC of Formula: C7H13BrO2, 14660-52-7, Name is Ethyl 5-bromovalerate, molecular formula is C7H13BrO2, belongs to bromides-buliding-blocks compound. In a document, author is Santos, Aila O., introduce the new discover.

The formate electrooxidation on Pt/C and PtSnO2/C nanoparticles in alkaline media: The effect of morphology and SnO2 on the platinum catalytic activity

Pt/C and PtSnO2/C electrocatalysts with and without cubic preferential morphology were used for formate electrooxidation reaction (FER) in alkaline medium. The synthesis of catalysts was carried out by alcohol reduction method using KBr as a shape directing agent (Bromide Anion Exchange method BAE). The X-ray diffraction (XRD) showed characteristic peaks of the Pt face-centered cubic (FCC) structure, as well as cassiterite SnO2. The Transmission Electron Microscopy (TEM) and Scanning Transmission Electron Microscopy (STEM) micrographs show SnO2 dispersed onto carbon support and adjacent to the Pt nanoparticles (NPs), as well as cubic Pt NPs. The cyclic voltammetry (CV) measurements show that the current density peak for FER on Pt/C (100) is 2.40 times higher than on Pt/C polycrystalline (poly). The current density at end of chronoamperometry (CA) analysis on PtSnO2/C poly was 1.33 and 5.29 times higher than on Pt/C (100) and Pt/C poly, respectively. The presence of SnO2 and the (100) facets of platinum cubic morphology might prevent platinum surface deactivation caused by intermediates formed during the FER process. (C) 2020 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 14660-52-7. HPLC of Formula: C7H13BrO2.

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Category: bromides-buliding-blocks, 95-56-7, Name is 2-Bromophenol, molecular formula is C6H5BrO, belongs to bromides-buliding-blocks compound. In a document, author is Potikha, Lyudmila M., introduce the new discover.

A novel method for the synthesis of pyrido[1,2-b][2]benzazepines on the basis of 2-(bromomethyl)benzophenones and 2-(bromomethyl)benzaldehyde

A novel method for the synthesis of pyrido[1,2-b][2]benzazepine derivatives is based on the reaction of 2-(bromomethyl)benzophenones and 2-(bromomethyl)benzaldehyde with 2-methylpyridines. The route of synthesis of 6H-pyrido[1,2-b][2]benzazepinium salts includes several steps with the possibility of isolating intermediate 1-benzyl-2-methylpyridinium and 11-aryl-11-hydroxy-11,12-dihydro-6Hpyrido[1,2-b][2]benzazepinium bromides. The efficiency of dehydration of intermediate carbinols increases with the use of protic solvents, an increase in heating time, and in the presence of electron-withdrawing substituents in the benzazepine moiety. The structure of the reaction products was proved by mass spectrometry, IR and one- and two-dimensional correlation NMR spectroscopy.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 95-56-7. Category: bromides-buliding-blocks.

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 766-96-1, Name is 1-Bromo-4-ethynylbenzene. In a document, author is Gedda, Murali, introducing its new discovery. Name: 1-Bromo-4-ethynylbenzene.

Ruddlesden-Popper-Phase Hybrid Halide Perovskite/Small-Molecule Organic Blend Memory Transistors

Controlling the morphology of metal halide perovskite layers during processing is critical for the manufacturing of optoelectronics. Here, a strategy to control the microstructure of solution-processed layered Ruddlesden-Popper-phase perovskite films based on phenethylammonium lead bromide ((PEA)(2)PbBr4) is reported. The method relies on the addition of the organic semiconductor 2,7-dioctyl[1]benzothieno[3,2-b]benzothiophene (C-8-BTBT) into the perovskite formulation, where it facilitates the formation of large, near-single-crystalline-quality platelet-like (PEA)(2)PbBr4 domains overlaid by a approximate to 5-nm-thin C-8-BTBT layer. Transistors with (PEA)(2)PbBr4/C-8-BTBT channels exhibit an unexpectedly large hysteresis window between forward and return bias sweeps. Material and device analysis combined with theoretical calculations suggest that the C-8-BTBT-rich phase acts as the hole-transporting channel, while the quantum wells in (PEA)(2)PbBr4 act as the charge storage element where carriers from the channel are injected, stored, or extracted via tunneling. When tested as a non-volatile memory, the devices exhibit a record memory window (>180 V), a high erase/write channel current ratio (10(4)), good data retention, and high endurance (>10(4) cycles). The results here highlight a new memory device concept for application in large-area electronics, while the growth technique can potentially be exploited for the development of other optoelectronic devices including solar cells, photodetectors, and light-emitting diodes.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 766-96-1 help many people in the next few years. Name: 1-Bromo-4-ethynylbenzene.