Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5279-32-3, name is 5,6-Dibromobenzo[d][1,3]dioxole, A new synthetic method of this compound is introduced below., Safety of 5,6-Dibromobenzo[d][1,3]dioxole
A stirred solution of 5,6-dibromobenzo[d][1,3]dioxole S6 (400 mg, 1.43 mmol) in toluene (15 mL) was cooled at -78 C, and freshly distilled furan (0.51 mL, 7.15 mmol) was added to the solution. n-BuLi (1.38 M in THF, 1.14 mL, 1.57 mmol) was added dropwise to the resulting solution over 5 minutes at -78 C. The reaction mixture was stirred for 10 additional minutes before it was warmed up to -40 C. Stirringwas continued for another 2 hours before water (20 mL) was added to quench the reaction. The organic layerwas separated and the aqueous layer was extracted with Et2O (4 x 10 mL). The combined organic extracts were washed with brine (20 mL), dried over Na2SO4, and concentrated in vacuo. Purification by column chromatography on silica gel, eluting with PET/Et2O (80:20), afforded 5,8-dihydro-5,8-epoxynaphtho[2,3-d][1,3]dioxole S7 (241 mg, 1.28 mmol, 90 %) as a white crystalline solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Antien, Kevin; Viault, Guillaume; Pouysegu, Laurent; Peixoto, Philippe A.; Quideau, Stephane; Tetrahedron; vol. 73; 26; (2017); p. 3684 – 3690;,
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