Reference of 106-37-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 106-37-6 name is 1,4-Dibromobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To synthesize intermediate compound 16a, octylmagnesium bromide solution (2.0 M in diethyl ether, 10.6 mL, 21 .2 mmol) is added dropwise to a diethyl ether solution (12.5 mL) of 1 ,4-dibromobenzene (5 g, 21 .2 mmol) and PdCI2(dppf) at 0 C under argon. After stirring 48 h at room temperature, the mixture is refluxed for 2.5 h, exposed to air, poured into water and extracted three times with diethyl ether. The combined organic layers are washed with brine, dried over MgSO4 and filtered. The solvent is removed under reduced pressure and the residue is purified by preparative thin-layer chromatography (20 x 20 cm, 1000 pm, 4 plates in hexane) to give compound 16a (4.4 g, 77 %) as a colorless oil. The product contained a minor impurity and is used as such in the subsequent reaction.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,4-Dibromobenzene, and friends who are interested can also refer to it.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE UNIVERSITE DE MONTREAL; EDINGER, Aimee; HANESSIAN, Stephen; (172 pag.)WO2017/53990; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary