Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 261723-28-8, name is (3-Bromo-2-fluorophenyl)methanamine, A new synthetic method of this compound is introduced below., COA of Formula: C7H7BrFN
Example 61 1,1-Dimethylethyl [(3-bromo-2-fluorophenyl)methyl]carbamate To a suspension of [(3-bromo-2-fluorophenyl)methyl]amine (5.0 g, 20.3 mmol) and Na2CO3 (5.5 g, 51.9 mmol) in CH2Cl2 (100 mL), the solution of Boc2O (4.5 g, 20.6 mmol) in CH2Cl2 (10 ml) was added dropwise. Then the reaction mixture was stirred overnight at room temperature. After filtration, the solid was washed with CH2Cl2 (50 mL*2), and then the filtrate was washed with water (70 mL*2), brine (70 mL*2) and dried over Na2SO4. After removing the solvent, 5.6 g of 1,1-dimethylethyl [(3-bromo-2-fluorophenyl)methyl]carbamate was obtained (yield: 94%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Glaxo Group Limited; US2009/197871; (2009); A1;,
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