In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 2-(4-Bromophenyl)-1,1-diphenylethylene
For 500 ml three-necked flask was added (2-(4-bromophenyl)ethene-1,1-diyl)dibenzene (10.1g, 30mmol) and 4-aminophenylboronic acid hydrochloride (6.07g, 35mmol). Add 200 ml tetrahydrofuran, stirring to form a uniform clear solution. Add 90 ml K2CO3 solution (2M). Under Ar gas protection, raise temperature to 80 C, rapidly add 0.02g Pd(PPh3)4. Stirring reflux reaction 24h. Cooling to room temperature, separating takes organically phase, the aqueous phase is CH2Cl2Extraction two times, the combined organic phase, adding anhydrous MgSO4Drying. Pumping the filtrate, mixes the silica gel decompression turns on lathe does solvent, in order to CH2Cl2/Normal hexane as eluent for column chromatography, collecting ultraviolet ray, turns on lathe does solvent under reduced pressure, vacuum drying, be pale yellow green powder 9.61g, yield 92%.
The synthetic route of 18648-66-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sun Yat-sen University; Zhang, Yi; Zhou, Zhuxin; Xu, Jiarui; Liu, Siwei; Chi, Zhenguo; (13 pag.)CN106565617; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary