These common heterocyclic compound, 630-17-1, name is 1-Bromo-2,2-dimethylpropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-Bromo-2,2-dimethylpropane
Step 3: 4-Bromo-2-terf-butyl-6-(neopentyloxy)pyridine (P8c) To a solution of compound P8b (2.0 g, 8.66 mmol) in dry DMF (20 ml_) was added NaH (0.62 g, 26.0 mmol) under N2 and the mixture was stirred at rt for 1 h. Then 1-bromo-2,2- dimethylpropane (2.37 g, 15.7 mmol) was added and the resulting mixture was heated at 80C overnight, quenched with water (10 ml_) and extracted with EA twice. The combined organic layers were washed with brine (3x), concentrated and purified by CC (PE/EA = 50/1) to give compound P8c (0.5 g, 20%) as an oil.
The synthetic route of 1-Bromo-2,2-dimethylpropane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas; WO2013/79223; (2013); A1;,
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