Month: May 2021

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41825-73-4, name is 2-Bromo-4,6-dimethylaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Bromo-4,6-dimethylaniline

a) Synthesis of A/-(2-bromo-4,6-dirnethyl-phenyl)-iH-benzimidazol-2-amine 2-Chlorobenzimidazole (6.9 g, 45.4 mmol) and 2-bromo-4,6-dimethylaniline (10.0 g, 50.0 mmol) are dissolved in NMP (23 imL) at 20C. Methanesulfonic acid (4.8 g, 50.0 mmol) is added dropwise over ca. 0.5 h. The resulting suspension is heated to 100C and stirred until complete conversion of 2-chlorobenzimidazole. The reaction mixture is then cooled to 20C, diluted with water (14 ml.) and neutralized with 30 w-% aqueous sodium hydroxide (12.7 g, 95.3 mmol). The precipitated reaction product is isolated by filtration, washed with water and dried under vacuum at 90C. Crude A/-(2-bromo-4,6-dimethyl-phenyl)- iH- benzimidazol-2-amine (10.3 g, 72%) is obtained as an off-white amorphous solid, which was further purified by recrystallization from methanol. 1 H-NMR (DMSO-d6): delta = 2.21 (s, 3H), 2.31 (s, 3H), 6.83-6.95 (m, 2H), 7.06-7.18 (m, 3H), 7.39 (brs, 1 H), 8.58 (brs, 1 H), 10.75 (brs, 1 H) ppm.

The synthetic route of 41825-73-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UDC IRELAND LIMITED; GREEF, DE, Michiel; PETER, Bernd; STUMPF, Ruediger; (36 pag.)WO2017/17096; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 261723-28-8, name is (3-Bromo-2-fluorophenyl)methanamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 261723-28-8

TEA (2.11 g, 20.88 mmol) and B0C2O (1.67 g, 7.66 mmol) were added to a solution of Compound BDl l-4 (1.42 g, 6.96 mmol) in DCM (30.00 mL). The mixture was stirred at 15C for 12 hours. LCMS showed the production of BD11-5. The reaction was concentrated to give a residue. The residue was purified by column chromatography (S1O2, petroleum ether: ethyl acetate mixture with a ratio of 30: 1 to 10: 1) to afford Compound BD11-5 (2.00 g, crude) as a white solid.

The synthetic route of 261723-28-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE BROAD INSTITUTE, INC.; VACCA, Joseph, P.; (103 pag.)WO2018/75871; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 18869-30-2, name is (E)-1,2-Bis(4-bromophenyl)ethene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18869-30-2, Recommanded Product: (E)-1,2-Bis(4-bromophenyl)ethene

EXAMPLE 3 Ethyl 4-bromostilbene-4′-acrylate. 25.8 g (0.1 mol) of 4,4′-dibromostilbene, 10 g (0.1 mol) of ethyl acrylate, 18.5 g (0.1 mol) of tri-n-butylamine, 0.224 g (0.001 mol) of palladium acetate and 0.6 g (0.002 mol) of tri-o-tolylphosphine are added under argon to 50 ml of p-xylene. The reaction mixture is stirred at 90 C. for 4 hours. Working up gives 2 g (6% of theory) of ethyl 4-bromostilbene-4′-acrylate. Melting point 166.9 C.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Ciba-Geigy Corporation; US4918215; (1990); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6698-13-1, name is 4-Bromo-1,3-benzodioxole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4-Bromo-1,3-benzodioxole

To a stirred solution of 4-bromo-1,3-benzodioxole (65 mg, 0.323 mmol, 1 eq.) and chloro(di-2-norbornylphosphino)(2’dimethylamino-1,1′-biphenyl-2-yl)palladium (II) (18 mg) in anhydrous dioxane (3 mL) under nitrogen2 is added a dioxane (3 mL) solution of [3-(tert-butyl-diphenyl-silanyloxy)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-pyridin-3-yl-amine (196 mg, 0.356 mmol, 1.1 eq) followed by 2M aqueous K3PO4 (0.35 mL, 0.7 mmol). The mixture is heated to 100 C. in a sealed tube overnight. The reaction mixture was returned to ambient temperature, and diluted with methylene chloride. The organic phase washed with brine, dried over MgSO4, filtered and concentrated to a dark brown oil. Flash chromatography (1% MeOH/methylene chloride) gave 117 mg of 3-benzo[1,3]dioxol-4-yl-5-(tert-butyl-diphenyl-silanyloxy)-phenyl]-pyridin-3-yl-amine as a beige solid.

According to the analysis of related databases, 6698-13-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kelly, Martha; Lee, Younghee; Liu, Bin; Fujimoto, Ted; Freundlich, Joel; Dorsey, Bruce D.; Flynn, Gary A.; Husain, Arifa; US2006/270686; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 105309-59-9, name is Tetrakis(4-bromophenyl)methane, A new synthetic method of this compound is introduced below., Application In Synthesis of Tetrakis(4-bromophenyl)methane

(a) Add tetra-[4-bromo-phenyl]methane 0.636 g (1 mmoL) and tetrakistriphenylphosphine palladium 0.18 g to a 50 mL two-necked round bottom flask and add toluene/tetrahydrofuran mixed solvent 20 mL under a vacuum of nitrogen. (volume ratio is 1:1), stir and dissolve uniformly, then inject 3-butylthiophene tributyl group 3.642g (8mmoL), raise the temperature to 140C, and react for 24 hours under light-proof conditions. After the reaction was completed, the mixture was extracted with methylene chloride, and the extract was spin-dried and separated by a column. Silica gel was used as a filler, and petroleum ether and methylene chloride (4:1 by volume) were used as eluent to give a pale yellow product (0.39 g). The yield is 40%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Zhejiang University of Technology; Zhang Cheng; Dai Yuyu; Li Weijun; Yan Shuanma; Qu Xingxing; Chen Lan; (11 pag.)CN107188902; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 40422-70-6, These common heterocyclic compound, 40422-70-6, name is 1-Bromo-3-(2-bromoethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Table 3 is a parameter table. The starting material “parameter 1” was added into a flask at room temperature under N2, and then the “parameter 2” mL IPA and “parameter 3” were added thereinto. The starting material was dissolved at “parameter 4” C. The appearances of reaction solution were “parameter 5” and “parameter 7” in about “parameter 6” minutes, and then the solution was heated at 110~120C for “parameter 8” hours and concentrated in room temperature. The “parameter 9” mL MeOH was added and the resulting mixture was stirred for “parameter 10” minutes. To the solution, which is “parameter 1 1” in a ice-bath, NaBH4(s) “parameter 12” was added slowly under N 2 and stirred for “parameter 13” minutes. The solution, which is “parameter 14,” was added with “parameter 15” mL H2O and extracted with “parameter 16” mL CHC13. The organic layer was added with MgS04 for drying, stirred for “parameter 17” minutes, filtered, and concentrated to obtain “parameter 18”. The “parameter 20” was afforded after flash column chromatography (silica gel, “parameter 19”).

Statistics shows that 1-Bromo-3-(2-bromoethyl)benzene is playing an increasingly important role. we look forward to future research findings about 40422-70-6.

Reference:
Patent; YU, Linda Chia-Hui; HSIN, Ling-Wei; LEE, Tsung-Chun; (0 pag.)WO2018/157233; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 89523-51-3,Some common heterocyclic compound, 89523-51-3, name is 5-Bromobenzo[c]phenanthrene, molecular formula is C18H11Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under an argon atmosphere, 3.07g of the 5-bromobenzo[c]phenanthrene which had been prepared in Synthesis Example 1, 4.18g of 10-(2-naphthyl)anthracene -9-boronic acid which had been synthesized by a known method, 0.231 g of tetraxis(triphenylphosphine)palladium(0), 40 mL of toluene and 20 mL of a 2M aqueous solution of sodium carbonate were charged. The resultant was refluxed with stirring for 8 hours. After cooling to room temperature, the reaction solution was extracted with toluene. An aqueous phase was removed, and an organic phase which had been separated was washed with water and saturated brine sequentially, and then dried with magnesium sulfate. After the magnesium sulfate was filtered out, the organic phase was concentrated. The resulting residue was purified by a silica gel column chromatography, whereby 4.13g of pale yellow crystals were obtained. As a result of mass spectrometry, the resulting crystals were confirmed to be the above-mentioned compound 1. The compound 1 had an m/e value of 530 with respect to a molecular weight of 530.20.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromobenzo[c]phenanthrene, its application will become more common.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2218706; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1435-54-7, name is 1,3-Dibromo-2-fluorobenzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H3Br2F

Scheme 4-1: In Step 1 the appropriately substituted dibromo species is coupled with an appropriate boronic acid as known in the art to form a mixture of biaryl and triaryl products from which the desired biaryl compound is isolated. In Step 2 the appropriately substituted biaryl species is converted to the Grignard reagent with activated magnesium. In Step 3 the appropriately substituted aldehyde is treated with the previously prepared Grignard reagent to form an alcohol. In Step 4 the appropriately substituted alcohol is converted to a bromide as known in the art with carbon tetrabromide and triphenyl phosphine. In Step 5 the appropriately substituted bromide is converted to the Grignard reagent with activated magnesium.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason Allan; PHADKE, Avinash S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (358 pag.)WO2017/35411; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 959992-62-2, name is 6-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 959992-62-2

Step 5 To a solution of Compound (10) (2.50 g, 11.6 mmol) in dimethylformamide (20 mL), triethylamine (4.8 mL), 34.9 mmol) and phenylisocyanate (1.6 mL, 15.1 mmol) were added. The solution was then stirred at 25 C for 24 hours. Water (3.0 mL) was then added to the reaction solution. The precipitated powder was filtered, washed with water, and then dried to yield subject compound I-113 (3.4 g, 85%) as a pale brown powder.1H-NMR (DMSO-d6) delta11.92 (1H, s), 7.52-7.55 (2H, m), 7.34-7.40 (3H, m), 7.28 (1H, dd, J = 8.4 Hz, J = 1.5 Hz), 4.30 (2H, t, J = 4.8 Hz), 4.04 (2H, t, J = 4.8 Hz) LC/MS (Method A): 2.45 min, [M+H]+ = 334.0.

The synthetic route of 959992-62-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shionogi & Co., Ltd.; EP2341052; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 141215-32-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 141215-32-9 as follows.

First, the amine compound (10 g, 30.8 mmol) obtained in Step 2 was dissolved in dehydrated pyridine (300 ml) in a 1,000 ml three-necked flask under Ar gas, and N-thionylaniline(9.5 g, 66 mmol) and trimethylsilyl chloride (39.5 g, 363.5 mmol) were added. Thereafter, the internal temperature was raised to 80 C., and the mixture was stirred overnight.Then, the reaction solution was cooled to room temperature and poured into water (200 ml). Precipitated crystals were collected by filtration, and the solid was washed with THF / n-hexane to obtain 6 g of a solid (crystal).Thereafter, purification was carried out by silica gel chromatography (silica gel 300 g, developing solvent chlorobenzene / hexane = 10: 3) (yield 3 g, yield 27.6%)

According to the analysis of related databases, 141215-32-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Seiko Epson Corporation; Tetsuji, Fujita; Yamamoto, Hidetoshi; Hamade, Yuiga; (64 pag.)JP2018/111679; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary